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Thermoresponsive Zinc TetraPhenylPorphyrin Photosensitizer/Dextran Graft Poly(N-IsoPropylAcrylAmide) Copolymer/Au Nanoparticles Hybrid Nanosystem: Potential for Photodynamic Therapy Applications.
Yeshchenko, Oleg A; Kutsevol, Nataliya V; Tomchuk, Anastasiya V; Khort, Pavlo S; Virych, Pavlo A; Chumachenko, Vasyl A; Kuziv, Yulia I; Marinin, Andrey I; Cheng, Lili; Nie, Guochao.
Afiliación
  • Yeshchenko OA; Physics Department, Taras Shevchenko National University of Kyiv, 60 Volodymyrska Str., 01601 Kyiv, Ukraine.
  • Kutsevol NV; Chemistry Department, Taras Shevchenko National University of Kyiv, 60 Volodymyrska Str., 01601 Kyiv, Ukraine.
  • Tomchuk AV; Institute Charles Sadron, 23 Rue du Loess, 67200 Strasbourg, France.
  • Khort PS; Physics Department, Taras Shevchenko National University of Kyiv, 60 Volodymyrska Str., 01601 Kyiv, Ukraine.
  • Virych PA; Physics Department, Taras Shevchenko National University of Kyiv, 60 Volodymyrska Str., 01601 Kyiv, Ukraine.
  • Chumachenko VA; Chemistry Department, Taras Shevchenko National University of Kyiv, 60 Volodymyrska Str., 01601 Kyiv, Ukraine.
  • Kuziv YI; Chemistry Department, Taras Shevchenko National University of Kyiv, 60 Volodymyrska Str., 01601 Kyiv, Ukraine.
  • Marinin AI; Chemistry Department, Taras Shevchenko National University of Kyiv, 60 Volodymyrska Str., 01601 Kyiv, Ukraine.
  • Cheng L; Institute Charles Sadron, 23 Rue du Loess, 67200 Strasbourg, France.
  • Nie G; Problem Research Laboratory, National University of Food Technology, 68 Volodymyrska Str., 01601 Kyiv, Ukraine.
Nanomaterials (Basel) ; 12(15)2022 Aug 02.
Article en En | MEDLINE | ID: mdl-35957085
The thermoresponsive Zinc TetraPhenylPorphyrin photosensitizer/Dextran poly (N-isopropylacrylamide) graft copolymer/Au Nanoparticles (ZnTPP/D-g-PNIPAM/AuNPs) triple hybrid nanosystem was synthesized in aqueous solution as a nanodrug for potential use in thermally driven and controlled photodynamic therapy applications. The aqueous solution of the nanosystem has demonstrated excellent stability in terms of aggregation and sedimentation several days after preparation. Optimal concentrations of the components of hybrid nanosystem providing the lowest level of aggregation and the highest plasmonic enhancement of electronic processes in the photosensitizer molecules have been determined. It has been revealed that the shrinking of D-g-PNIPAM macromolecule during a thermally induced phase transition leads to the release of both ZnTPP molecules and Au NPs from the ZnTPP/D-g-PNIPAM/AuNPs macromolecule and the strengthening of plasmonic enhancement of the electronic processes in ZnTPP molecules bound with the polymer macromolecule. The 2.7-fold enhancement of singlet oxygen photogeneration under resonant with surface plasmon resonance has been observed for ZnTPP/D-g-PNIPAM/AuNPs proving the plasmon nature of such effect. The data obtained in vitro on wild strains of Staphylococcus aureus have proved the high potential of such nanosystem for rapid photodynamic inactivation of microorganisms particular in wounds or ulcers on the body surface.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Nanomaterials (Basel) Año: 2022 Tipo del documento: Article País de afiliación: Ucrania Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Nanomaterials (Basel) Año: 2022 Tipo del documento: Article País de afiliación: Ucrania Pais de publicación: Suiza