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Synthesis and Characterization of Dendronized Gold Nanoparticles Bearing Charged Peripheral Groups with Antimicrobial Potential.
Perli, Gabriel; Bertuzzi, Diego L; Souto, Dênio E P; Ramos, Miguel D; Braga, Carolyne B; Aguiar, Samile B; Ornelas, Catia.
Afiliación
  • Perli G; Institute of Chemistry, University of Campinas, Campinas 13083-970, Brazil.
  • Bertuzzi DL; Institute of Chemistry, University of Campinas, Campinas 13083-970, Brazil.
  • Souto DEP; Institute of Chemistry, University of Campinas, Campinas 13083-970, Brazil.
  • Ramos MD; Laboratorio de Espectrometria, Sensores e Biossensores, Departamento de Quimica, Universidade Federal do Paraná (UFPR), Curitiba 81531-980, Brazil.
  • Braga CB; Institute of Chemistry, University of Campinas, Campinas 13083-970, Brazil.
  • Aguiar SB; Institute of Chemistry, University of Campinas, Campinas 13083-970, Brazil.
  • Ornelas C; Institute of Chemistry, University of Campinas, Campinas 13083-970, Brazil.
Nanomaterials (Basel) ; 12(15)2022 Jul 29.
Article en En | MEDLINE | ID: mdl-35957042
Dendronized gold nanoparticles (AuNPs) were synthesized bearing charged peripheral groups. Two novel AB3-type dendrons were synthesized with a thiol group at the focal point followed by their attachment to AuNPs. Dendrons were designed to have nine charged peripheral groups (carboxyl or amine), glycol solubilizing, units and one thiol moiety at the focal point. Both dendrons and all intermediates were synthesized in high yields and characterized by nuclear magnetic resonance spectroscopy (NMR) and mass spectrometry (MS). The amine- and carboxyl-terminated dendrons were used to functionalize gold nanoparticles (AuNPs) previously stabilized with citrate. The nanoparticles' diameters and their colloidal stability were investigated using dynamic light scattering (DLS). The size and morphology of the dendronized AuNPs were evaluated by scanning electron microscopy (SEM), which revealed individual particles with no aggregation after replacement of citrate by the dendrons, in agreement with the DLS data. The absorption spectroscopy reveals a prominent plasmonic band at 560 nm for all AuNPs. The zeta potential further confirmed the expected charged structures of the dendronized AuNPs. Considering all the physical-chemical properties of the charged dendronized AuNPs developed in this work, these AuNPs might be used as a weapon against multi-drug resistant bacterial infections.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Nanomaterials (Basel) Año: 2022 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Nanomaterials (Basel) Año: 2022 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Suiza