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Protective Effects of Recombinant Human Angiogenin in Keratinocytes: New Insights on Oxidative Stress Response Mediated by RNases.
Culurciello, Rosanna; Bosso, Andrea; Troisi, Romualdo; Barrella, Valentina; Di Nardo, Ilaria; Borriello, Margherita; Gaglione, Rosa; Pistorio, Valeria; Aceto, Serena; Cafaro, Valeria; Notomista, Eugenio; Sica, Filomena; Arciello, Angela; Pizzo, Elio.
Afiliación
  • Culurciello R; Department of Biology, University of Naples Federico II, 80126 Naples, Italy.
  • Bosso A; Centro Servizi Metrologici e Tecnologici Avanzati (CeSMA), University of Naples Federico II, 80126 Naples, Italy.
  • Troisi R; Department of Biology, University of Naples Federico II, 80126 Naples, Italy.
  • Barrella V; Department of Chemical Sciences, University of Naples Federico II, 80126 Naples, Italy.
  • Di Nardo I; Department of Biology, University of Naples Federico II, 80126 Naples, Italy.
  • Borriello M; Department of Biology, University of Naples Federico II, 80126 Naples, Italy.
  • Gaglione R; Department of Precision Medicine, University of Campania "Luigi Vanvitelli", Via L. De Crecchio 7, 80138 Naples, Italy.
  • Pistorio V; Department of Chemical Sciences, University of Naples Federico II, 80126 Naples, Italy.
  • Aceto S; Department of Chemical Sciences, University of Naples Federico II, 80126 Naples, Italy.
  • Cafaro V; Department of Biology, University of Naples Federico II, 80126 Naples, Italy.
  • Notomista E; Department of Biology, University of Naples Federico II, 80126 Naples, Italy.
  • Sica F; Department of Biology, University of Naples Federico II, 80126 Naples, Italy.
  • Arciello A; Department of Chemical Sciences, University of Naples Federico II, 80126 Naples, Italy.
  • Pizzo E; Department of Chemical Sciences, University of Naples Federico II, 80126 Naples, Italy.
Int J Mol Sci ; 23(15)2022 Aug 07.
Article en En | MEDLINE | ID: mdl-35955913
Human angiogenin (ANG) is a 14-kDa ribonuclease involved in different pathophysiological processes including tumorigenesis, neuroprotection, inflammation, innate immunity, reproduction, the regeneration of damaged tissues and stress cell response, depending on its intracellular localization. Under physiological conditions, ANG moves to the cell nucleus where it enhances rRNA transcription; conversely, recent reports indicate that under stress conditions, ANG accumulates in the cytoplasmic compartment and modulates the production of tiRNAs, a novel class of small RNAs that contribute to the translational inhibition and recruitment of stress granules (SGs). To date, there is still limited and controversial experimental evidence relating to a hypothetical role of ANG in the epidermis, the outermost layer of human skin, which is continually exposed to external stressors. The present study collects compelling evidence that endogenous ANG is able to modify its subcellular localization on HaCaT cells, depending on different cellular stresses. Furthermore, the use of recombinant ANG allowed to determine as this special enzyme is effectively able to counter at various levels the alterations of cellular homeostasis in HaCaT cells, actually opening a new vision on the possible functions that this special enzyme can support also in the stress response of human skin.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ribonucleasas / ARN de Transferencia Límite: Humans Idioma: En Revista: Int J Mol Sci Año: 2022 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Suiza
Texto completo
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XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ribonucleasas / ARN de Transferencia Límite: Humans Idioma: En Revista: Int J Mol Sci Año: 2022 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Suiza