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Therapeutic Vaccines for HPV-Associated Oropharyngeal and Cervical Cancer: The Next De-Intensification Strategy?
Morand, Grégoire B; Cardona, Isabel; Cruz, Sara Brito Silva Costa; Mlynarek, Alex M; Hier, Michael P; Alaoui-Jamali, Moulay A; da Silva, Sabrina Daniela.
Afiliación
  • Morand GB; Department of Otolaryngology Head and Neck Surgery, Sir Mortimer B. Davis-Jewish General Hospital, McGill University, Montreal, QC H3T 1E2, Canada.
  • Cardona I; Department of Otolaryngology Head and Neck Surgery, Luzerner Kantonsspital, 6004 Lucerne, Switzerland.
  • Cruz SBSC; Department of Obstetrics and Gynecology, Montreal University Health Center, McGill University, Montreal, QC H3T 1E2, Canada.
  • Mlynarek AM; Department of Otolaryngology Head and Neck Surgery, Sir Mortimer B. Davis-Jewish General Hospital, McGill University, Montreal, QC H3T 1E2, Canada.
  • Hier MP; Segal Cancer Centre and Lady Davis Institute for Medical Research, Sir Mortimer B. Davis-Jewish General Hospital, Departments of Medicine and Oncology, Faculty of Medicine, McGill University, Montreal, QC H3T 1E2, Canada.
  • Alaoui-Jamali MA; Human Immunology Research and Education, Federal University of Paraiba, João Pessoa 58059-900, PB, Brazil.
  • da Silva SD; Graduate Program in Dentistry, Federal University of Paraiba, João Pessoa 58059-900, PB, Brazil.
Int J Mol Sci ; 23(15)2022 Jul 29.
Article en En | MEDLINE | ID: mdl-35955529
The rise in human papillomavirus (HPV)-associated oropharyngeal squamous cell carcinoma (OPSCC) has prompted a quest for further understanding of the role of high-risk HPV in tumor initiation and progression. Patients with HPV-positive OPSCC (HPV+ OPSCC) have better prognoses than their HPV-negative counterparts; however, current therapeutic strategies for HPV+ OPSCC are overly aggressive and leave patients with life-long sequalae and poor quality of life. This highlights a need for customized treatment. Several clinical trials of treatment de-intensification to reduce acute and late toxicity without compromising efficacy have been conducted. This article reviews the differences and similarities in the pathogenesis and progression of HPV-related OPSCC compared to cervical cancer, with emphasis on the role of prophylactic and therapeutic vaccines as a potential de-intensification treatment strategy. Overall, the future development of novel and effective therapeutic agents for HPV-associated head and neck tumors promises to meet the challenges posed by this growing epidemic.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Vacunas / Neoplasias Orofaríngeas / Neoplasias del Cuello Uterino / Infecciones por Papillomavirus / Alphapapillomavirus / Neoplasias de Cabeza y Cuello Tipo de estudio: Risk_factors_studies Aspecto: Patient_preference Límite: Female / Humans Idioma: En Revista: Int J Mol Sci Año: 2022 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Suiza
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Vacunas / Neoplasias Orofaríngeas / Neoplasias del Cuello Uterino / Infecciones por Papillomavirus / Alphapapillomavirus / Neoplasias de Cabeza y Cuello Tipo de estudio: Risk_factors_studies Aspecto: Patient_preference Límite: Female / Humans Idioma: En Revista: Int J Mol Sci Año: 2022 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Suiza