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Boron attenuated diethylnitrosamine induced hepatocellular carcinoma in C3H/HeN mice via alteration of oxidative stress and apoptotic pathway.
Wei, Ying; Yi, Jin-Ke; Chen, Jun; Huang, Huimin; Wu, Lun; Yin, Xufeng; Wang, Jinjin.
Afiliación
  • Wei Y; Sinopharm Dongfeng General Hospital, Hubei University of Medicine, Shiyan, Hubei 442008, China.
  • Yi JK; Sinopharm Dongfeng General Hospital, Hubei University of Medicine, Rehabilitation department, Shiyan, Hubei 442008, China.
  • Chen J; Sinopharm Dongfeng General Hospital, Hubei University of Medicine, Shiyan, Hubei 442008, China.
  • Huang H; Sinopharm Dongfeng General Hospital, Hubei University of Medicine, Shiyan, Hubei 442008, China.
  • Wu L; Sinopharm Dongfeng General Hospital, Hubei University of Medicine, Shiyan, Hubei 442008, China.
  • Yin X; Sinopharm Dongfeng General Hospital, Hubei University of Medicine, Children's Medical Center, Shiyan, Hubei 442008, China. Electronic address: 38625350@qq.com.
  • Wang J; Sinopharm Dongfeng General Hospital, Hubei University of Medicine, Shiyan, Hubei 442008, China. Electronic address: 262479669@qq.com.
J Trace Elem Med Biol ; 74: 127052, 2022 Dec.
Article en En | MEDLINE | ID: mdl-35952449
BACKGROUND: Reactive oxygen species (ROS) regulate various cellular signaling pathways and play an important role in the occurrence and development of hepatocellular carcinoma (HCC). Excessive accumulation of ROS can promote HCC. Trace element boron has a wide range of biological effects, including anti-oxidation, anti-tumor, immune regulation and so on. METHODS: In this study, we investigated the anticancer effects of Sodium tetraborate decahydrate (NaB) in improving oxidative stress and regulating apoptosis in mouse HCC. HCC was induced by intraperitoneal injection of diethylnitrosamine (DEN) 25 mg/kg once at the age of 2 weeks and 100 mg/kg again at the age of 6 weeks in healthy C3H/HeN male mice. At 8 weeks of age, different concentrations of NaB were given intragastric treatment once a day for 20 weeks. Oxidative stress markers, antioxidant status and liver enzyme analysis were detected to evaluate the effectiveness of NaB in inhibiting cancer induction. The anticancer properties of NaB were confirmed by observing the liver index and morphology, and analyzing the expression of apoptotic genes and proteins. Our results showed that boron significantly reduced the production of ROS, and down-regulated the expression of the anti-apoptotic protein Bcl2 and up-regulated the expression of the pro-apoptotic proteins P53, Bax, and caspase 3. CONCLUSION: Boron has great potential to reduce the effects of oxidative stress, which may help it inhibit the progression of HCC.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Oligoelementos / Carcinoma Hepatocelular / Neoplasias Hepáticas Límite: Animals Idioma: En Revista: J Trace Elem Med Biol Asunto de la revista: METABOLISMO / SAUDE AMBIENTAL Año: 2022 Tipo del documento: Article País de afiliación: China Pais de publicación: Alemania
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Oligoelementos / Carcinoma Hepatocelular / Neoplasias Hepáticas Límite: Animals Idioma: En Revista: J Trace Elem Med Biol Asunto de la revista: METABOLISMO / SAUDE AMBIENTAL Año: 2022 Tipo del documento: Article País de afiliación: China Pais de publicación: Alemania