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Molecular architecture of bacterial type IV secretion systems.
Sheedlo, Michael J; Ohi, Melanie D; Lacy, D Borden; Cover, Timothy L.
Afiliación
  • Sheedlo MJ; Department of Pharmacology, University of Minnesota, Minneapolis, Minnesota, United States of America.
  • Ohi MD; Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, Michigan, United States of America.
  • Lacy DB; Life Sciences Institute, University of Michigan, Ann Arbor, Michigan, United States of America.
  • Cover TL; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America.
PLoS Pathog ; 18(8): e1010720, 2022 08.
Article en En | MEDLINE | ID: mdl-35951533
Bacterial type IV secretion systems (T4SSs) are a versatile group of nanomachines that can horizontally transfer DNA through conjugation and deliver effector proteins into a wide range of target cells. The components of T4SSs in gram-negative bacteria are organized into several large subassemblies: an inner membrane complex, an outer membrane core complex, and, in some species, an extracellular pilus. Cryo-electron tomography has been used to define the structures of T4SSs in intact bacteria, and high-resolution structural models are now available for isolated core complexes from conjugation systems, the Xanthomonas citri T4SS, the Helicobacter pylori Cag T4SS, and the Legionella pneumophila Dot/Icm T4SS. In this review, we compare the molecular architectures of these T4SSs, focusing especially on the structures of core complexes. We discuss structural features that are shared by multiple T4SSs as well as evolutionary strategies used for T4SS diversification. Finally, we discuss how structural variations among T4SSs may confer specialized functional properties.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Helicobacter pylori / Legionella pneumophila Idioma: En Revista: PLoS Pathog Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Helicobacter pylori / Legionella pneumophila Idioma: En Revista: PLoS Pathog Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos