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Diagnostic yield of screening for SARS-CoV-2 among patients admitted to hospital for alternate diagnoses: an observational cohort study.
Davis, Philip; Rosychuk, Rhonda; Hau, Jeffrey P; Cheng, Ivy; McRae, Andrew D; Daoust, Raoul; Lang, Eddy; Turner, Joel; Khangura, Jaspreet; Fok, Patrick T; Stachura, Maja; Brar, Baljeet; Hohl, Corinne M.
Afiliación
  • Davis P; Department of Emergency Medicine, University of Saskatchewan, Saskatchewan, Saskatoon, Canada phil.davis@usask.ca.
  • Rosychuk R; Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada.
  • Hau JP; Centre for Clinical Epidemiology and Evaluation, Vancouver Coastal Health Research Institute, Vancouver, British Columbia, Canada.
  • Cheng I; Department of Emergency Medicine, The University of British Columbia, Vancouver, British Columbia, Canada.
  • McRae AD; Department of Emergency Medicine, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada.
  • Daoust R; Department of Emergency Medicine, University of Toronto Faculty of Medicine, Toronto, Ontario, Canada.
  • Lang E; Department of Emergency Medicine, University of Calgary, Calgary, Alberta, Canada.
  • Turner J; Département Médecine de Famille et Médecine d'Urgence, Université de Montréal, Montreal, Quebec, Canada.
  • Khangura J; Department of Emergency Medicine, University of Calgary, Calgary, Alberta, Canada.
  • Fok PT; Department of Emergency Medicine, McGill University, Montreal, Quebec, Canada.
  • Stachura M; Department of Emergency Medicine, Northeast Community Health Centre, Edmonton, Alberta, Canada.
  • Brar B; Department of Emergency Medicine, Dalhousie University, Halifax, Nova Scotia, Canada.
  • Hohl CM; Department of Emergency Medicine, The University of British Columbia, Vancouver, British Columbia, Canada.
BMJ Open ; 12(8): e057852, 2022 08 10.
Article en En | MEDLINE | ID: mdl-35948378
OBJECTIVES: To determine the diagnostic yield of screening patients for SARS-CoV-2 who were admitted with a diagnosis unrelated to COVID-19 and to identify risk factors for positive tests. DESIGN: Cohort from the Canadian COVID-19 Emergency Department Rapid Response Network registry. SETTING: 30 acute care hospitals across Canada. PARTICIPANTS: Patients hospitalised for non-COVID-19-related diagnoses who were tested for SARS-CoV-2 between 1 March and 29 December 2020. MAIN OUTCOME: Positive nucleic acid amplification test for SARS-CoV-2. OUTCOME MEASURE: Diagnostic yield. RESULTS: We enrolled 15 690 consecutive eligible adults who were admitted to hospital without clinically suspected COVID-19. Among these patients, 122 tested positive for COVID-19, resulting in a diagnostic yield of 0.8% (95% CI 0.64% to 0.92%). Factors associated with a positive test included presence of fever, being a healthcare worker, having a positive household contact or institutional exposure, and living in an area with higher 7-day average incident COVID-19 cases. CONCLUSIONS: Universal screening of hospitalised patients for COVID-19 across two pandemic waves had a low diagnostic yield and should be informed by individual-level risk assessment in addition to regional COVID-19 prevalence. TRIAL REGISTRATION NUMBER: NCT04702945.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: SARS-CoV-2 / COVID-19 Tipo de estudio: Diagnostic_studies / Etiology_studies / Observational_studies / Risk_factors_studies / Screening_studies Límite: Adult / Humans País/Región como asunto: America do norte Idioma: En Revista: BMJ Open Año: 2022 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: SARS-CoV-2 / COVID-19 Tipo de estudio: Diagnostic_studies / Etiology_studies / Observational_studies / Risk_factors_studies / Screening_studies Límite: Adult / Humans País/Región como asunto: America do norte Idioma: En Revista: BMJ Open Año: 2022 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Reino Unido