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Mass spectrometry of short peptides reveals common features of metazoan peptidergic neurons.
Hayakawa, Eisuke; Guzman, Christine; Horiguchi, Osamu; Kawano, Chihiro; Shiraishi, Akira; Mohri, Kurato; Lin, Mei-Fang; Nakamura, Ryotaro; Nakamura, Ryo; Kawai, Erina; Komoto, Shinya; Jokura, Kei; Shiba, Kogiku; Shigenobu, Shuji; Satake, Honoo; Inaba, Kazuo; Watanabe, Hiroshi.
Afiliación
  • Hayakawa E; Evolutionary Neurobiology Unit, Okinawa Institute of Science and Technology Graduate University, Okinawa, Japan. eisuke.hayakawa@oist.jp.
  • Guzman C; Evolutionary Neurobiology Unit, Okinawa Institute of Science and Technology Graduate University, Okinawa, Japan.
  • Horiguchi O; Evolutionary Neurobiology Unit, Okinawa Institute of Science and Technology Graduate University, Okinawa, Japan.
  • Kawano C; Evolutionary Neurobiology Unit, Okinawa Institute of Science and Technology Graduate University, Okinawa, Japan.
  • Shiraishi A; Bioorganic Research Institute, Suntory Foundation for Life Sciences, Kyoto, Japan.
  • Mohri K; Evolutionary Neurobiology Unit, Okinawa Institute of Science and Technology Graduate University, Okinawa, Japan.
  • Lin MF; Evolutionary Neurobiology Unit, Okinawa Institute of Science and Technology Graduate University, Okinawa, Japan.
  • Nakamura R; College of Marine Sciences, National Sun Yat-Sen University, Kaohsiung, Taiwan.
  • Nakamura R; Evolutionary Neurobiology Unit, Okinawa Institute of Science and Technology Graduate University, Okinawa, Japan.
  • Kawai E; Evolutionary Neurobiology Unit, Okinawa Institute of Science and Technology Graduate University, Okinawa, Japan.
  • Komoto S; Evolutionary Neurobiology Unit, Okinawa Institute of Science and Technology Graduate University, Okinawa, Japan.
  • Jokura K; Marine Climate Change Unit, Okinawa Institute of Science and Technology Graduate University, Okinawa, Japan.
  • Shiba K; Evolutionary Neurobiology Unit, Okinawa Institute of Science and Technology Graduate University, Okinawa, Japan.
  • Shigenobu S; Imaging Section, Okinawa Institute of Science and Technology Graduate University, Okinawa, Japan.
  • Satake H; Shimoda Marine Research Center, University of Tsukuba, Shizuoka, Japan.
  • Inaba K; Living Systems Institute, University of Exeter, Exeter, UK.
  • Watanabe H; Shimoda Marine Research Center, University of Tsukuba, Shizuoka, Japan.
Nat Ecol Evol ; 6(10): 1438-1448, 2022 10.
Article en En | MEDLINE | ID: mdl-35941202
The evolutionary origins of neurons remain unknown. Although recent genome data of extant early-branching animals have shown that neural genes existed in the common ancestor of animals, the physiological and genetic properties of neurons in the early evolutionary phase are still unclear. Here, we performed a mass spectrometry-based comprehensive survey of short peptides from early-branching lineages Cnidaria, Porifera and Ctenophora. We identified a number of mature ctenophore neuropeptides that are expressed in neurons associated with sensory, muscular and digestive systems. The ctenophore peptides are stored in vesicles in cell bodies and neurites, suggesting volume transmission similar to that of cnidarian and bilaterian peptidergic systems. A comparison of genetic characteristics revealed that the peptide-expressing cells of Cnidaria and Ctenophora express the vast majority of genes that have pivotal roles in maturation, secretion and degradation of neuropeptides in Bilateria. Functional analysis of neuropeptides and prediction of receptors with machine learning demonstrated peptide regulation of a wide range of target effector cells, including cells of muscular systems. The striking parallels between the peptidergic neuronal properties of Cnidaria and Bilateria and those of Ctenophora, the most basal neuron-bearing animals, suggest a common evolutionary origin of metazoan peptidergic nervous systems.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cnidarios / Ctenóforos Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Nat Ecol Evol Año: 2022 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cnidarios / Ctenóforos Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Nat Ecol Evol Año: 2022 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Reino Unido