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Could red cell distribution width be used for predicting cardiac injury in neonates with COVID-19?
Elbayiyev, Sarkhan; Simsek, Gülsüm K; Ceran, Burak; Akin, Mustafa S; Kanmaz Kutman, H Gözde; Canpolat, Fuat E.
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  • Elbayiyev S; Department of Neonatology, Ankara City Hospital University of Health Sciences, Ankara, Bilkent, Turkey.
  • Simsek GK; Department of Neonatology, Ankara City Hospital University of Health Sciences, Ankara, Bilkent, Turkey.
  • Ceran B; Department of Neonatology, Ankara City Hospital University of Health Sciences, Ankara, Bilkent, Turkey.
  • Akin MS; Department of Neonatology, Ankara City Hospital University of Health Sciences, Ankara, Bilkent, Turkey.
  • Kanmaz Kutman HG; Department of Neonatology, Ankara City Hospital University of Health Sciences, Ankara, Bilkent, Turkey.
  • Canpolat FE; Department of Neonatology, Ankara City Hospital University of Health Sciences, Ankara, Bilkent, Turkey.
J Med Virol ; 94(12): 5739-5745, 2022 12.
Article en En | MEDLINE | ID: mdl-35938314
BACKGROUND: Coronavirus disease 2019 (COVID-19) can affect people of all age groups and it can occasionally cause life-threatening clinical illnesses in immunologically immature populations, especially in newborns. High red cell distribution width (RDW) values were used as an early prognostic biomarker of some neonatal diseases. We aimed to determine the prognostic value of RDW in severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) infected neonates. METHODS: Newborns with positive SARS-CoV-2 polymerase chain reaction (PCR) test from a nasopharyngeal swab sample, who had refractory fever (>38°C and lasting more than 24 h during hospitalization), were screened for multisystem inflammatory syndrome in newborns (MIS-N), systemic inflammatory indexes calculated and cardiologic evaluations. Due to troponin levels (high: >45 ng/L and low: ≤45 ng/L) patients were grouped. RESULTS: Out of the 68 SARS-CoV-2 PCR-positive newborns, 26 patients had refractory fever. Comparison of laboratory findings between the high and low-troponin groups showed that RDW and neutrophil/lymphocyte ratio values were significantly higher in patients with high troponin levels (p = 0.022 and p = 0.030, respectively). The cut-off values with optimal sensitivity and specificity were determined as 1.00 for neutrophil/lymphocyte ratio (p = 0.205) and 16.6 for RDW (p = 0.014). None of the patients died. CONCLUSIONS: Neonatal COVID-19 generally has a benign prognosis, but can progress to severe disease and cases of MIS-N are rare. RDW could be prognostic in the diagnosis and management of neonates with SARS-CoV-2 infection with high troponin levels.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: COVID-19 / Lesiones Cardíacas Tipo de estudio: Diagnostic_studies / Prognostic_studies / Risk_factors_studies Límite: Humans / Newborn Idioma: En Revista: J Med Virol Año: 2022 Tipo del documento: Article País de afiliación: Turquía Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: COVID-19 / Lesiones Cardíacas Tipo de estudio: Diagnostic_studies / Prognostic_studies / Risk_factors_studies Límite: Humans / Newborn Idioma: En Revista: J Med Virol Año: 2022 Tipo del documento: Article País de afiliación: Turquía Pais de publicación: Estados Unidos