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Misleading eosinophil counts in migration-associated malaria: do not miss hidden helminthic co-infections.
Castillo-Fernández, Nerea; Soriano-Pérez, Manuel J; Lozano-Serrano, Ana Belén; Luzón-García, María Pilar; Cabeza-Barrera, María Isabel; Vázquez-Villegas, José; Pérez-Moyano, Rosario; Moya-Ruíz, Alejandro; Salas-Coronas, Joaquín.
Afiliación
  • Castillo-Fernández N; Tropical Medicine Unit, Hospital de Poniente, El Ejido, Almería, Spain.
  • Soriano-Pérez MJ; Tropical Medicine Unit, Hospital de Poniente, El Ejido, Almería, Spain.
  • Lozano-Serrano AB; Tropical Medicine Unit, Hospital de Poniente, El Ejido, Almería, Spain.
  • Luzón-García MP; Tropical Medicine Unit, Hospital de Poniente, El Ejido, Almería, Spain.
  • Cabeza-Barrera MI; Tropical Medicine Unit, Hospital de Poniente, El Ejido, Almería, Spain.
  • Vázquez-Villegas J; Tropical Medicine Unit, Distrito Poniente, Almería, Spain.
  • Pérez-Moyano R; Hematology Unit, Hospital de Poniente, El Ejido, Almería, Spain.
  • Moya-Ruíz A; Tropical Medicine Unit, Hospital de Poniente, El Ejido, Almería, Spain.
  • Salas-Coronas J; Tropical Medicine Unit, Hospital de Poniente, El Ejido, Almería, Spain; Department of Nursing, Physiotherapy and Medicine, Faculty of Health Sciences. University of Almeria, Almeria, Spain. Electronic address: joaquin.salas.sspa@juntadeandalucia.es.
Travel Med Infect Dis ; 49: 102415, 2022.
Article en En | MEDLINE | ID: mdl-35934309
BACKGROUND: Lower eosinophil counts observed during acute malaria episodes could hide helminth-related eosinophilia. METHOD: Retrospective observational study with sub-Saharan migrants with imported malaria from May-2007 to May-2020. Absolute eosinophil count was determined upon diagnosis at hospital admission and at least once after clearance of parasitemia. Helminthic co-infections were investigated by searching for stool and urine parasites, serology for Strongyloides spp. and Schistosoma spp., and Knott and/or saponin tests for blood microfilariae. RESULTS: A total of 259 patients were included. Most of them were male (n = 237; 91.5%) and VFR travelers (n = 241; 93.1%). 131 patients (50.6%) were diagnosed with probable schistosomiasis, 15 (5.8%) with confirmed schistosomiasis, 16 (6.2%) with strongyloidiasis, 4 (1.6%) with soil-transmitted helminthiasis, and 4 (1.6%) with filariasis (Mansonella perstans). Prevalence of eosinophilia increased from 2.7% on admission to 32.5% during outpatient follow-up. Eosinophilia did not appear until several weeks after hospital discharge in up to 24% of the confirmed helminthic co-infections and in 61.1% of patients with probable schistosomiasis. Eosinophilia was associated with confirmed schistosomiasis and mansonellosis while 56.2% and 75% of cases with strongyloidiasis and soil-transmitted worms did not present eosinophilia at any time, respectively. CONCLUSIONS: Regardless of the absence of eosinophilia, patients hospitalized because of acute imported malaria might benefit from the screening of the main parasitic diseases, allowing for earlier diagnosis and treatment.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Esquistosomiasis / Estrongiloidiasis / Eosinofilia / Coinfección / Malaria Tipo de estudio: Diagnostic_studies / Etiology_studies / Observational_studies / Risk_factors_studies Límite: Female / Humans / Male Idioma: En Revista: Travel Med Infect Dis Asunto de la revista: DOENCAS TRANSMISSIVEIS Año: 2022 Tipo del documento: Article País de afiliación: España Pais de publicación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Esquistosomiasis / Estrongiloidiasis / Eosinofilia / Coinfección / Malaria Tipo de estudio: Diagnostic_studies / Etiology_studies / Observational_studies / Risk_factors_studies Límite: Female / Humans / Male Idioma: En Revista: Travel Med Infect Dis Asunto de la revista: DOENCAS TRANSMISSIVEIS Año: 2022 Tipo del documento: Article País de afiliación: España Pais de publicación: Países Bajos