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The prognostic significance of early blood neurofilament light chain concentration and magnetic resonance imaging variables in relapse-onset multiple sclerosis.
Williams, Thomas; Heslegrave, Amanda; Zetterberg, Henrik; Miszkiel, Katherine A; Barkhof, Frederik; Ciccarelli, Olga; Brownlee, Wallace J; Chataway, Jeremy.
Afiliación
  • Williams T; Queen Square Multiple Sclerosis Centre, Department of Neuroinflammation, UCL Queen Square Institute of Neurology, Faculty of Brain Sciences, University College London, London, UK.
  • Heslegrave A; National Hospital for Neurology and Neurosurgery, Queen Square, London, UK.
  • Zetterberg H; Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK.
  • Miszkiel KA; UK Dementia Research Institute at UCL, University College London, London, UK.
  • Barkhof F; Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK.
  • Ciccarelli O; UK Dementia Research Institute at UCL, University College London, London, UK.
  • Brownlee WJ; Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, the Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.
  • Chataway J; Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden.
Brain Behav ; 12(9): e2700, 2022 09.
Article en En | MEDLINE | ID: mdl-35925940
BACKGROUND: Improved prognostication remains vital in multiple sclerosis to inform personalized treatment approaches. Blood neurofilament light (bNfL) is a promising prognostic biomarker, but to what extent it provides additional information, independent of established MRI metrics, is yet to be established. METHODS: We obtained all available bNfL data for 133 patients from a longitudinal observational cohort study. Patients were dichotomized into good or poor outcome groups based upon clinical and cognitive assessments performed 15 years after a clinically isolated syndrome. We performed longitudinal modeling of early NfL and MRI variables to examine differences between outcome groups. RESULTS: The bNfL dataset was incomplete, with one to three (mean 1.5) samples available per participant. Within 3 months of onset, bNfL was similar between groups. The bNfL concentration subsequently decreased in those with a good outcome, and remained persistently elevated in those with a poor outcome. By year 5, NfL in the poor outcome group was approximately double that of those with a good outcome (14.58 [10.40-18.77] vs. 7.71 [6.39-9.04] pg/ml, respectively). Differences were reduced after adjustment for longitudinal changes in T2LV, but trends persisted for a greater rate of increase in NfL in those with a poor outcome, independent of T2LV. CONCLUSIONS: This analysis requires replication in cohorts with more complete bNfL datasets, but suggests that persistently elevated blood NfL may be more common in patients with a poor long-term outcome. Persistent elevation of blood NfL may provide additional prognostic information not wholly accounted for by standard monitoring techniques.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Esclerosis Múltiple Tipo de estudio: Observational_studies / Prognostic_studies Límite: Humans Idioma: En Revista: Brain Behav Año: 2022 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Esclerosis Múltiple Tipo de estudio: Observational_studies / Prognostic_studies Límite: Humans Idioma: En Revista: Brain Behav Año: 2022 Tipo del documento: Article Pais de publicación: Estados Unidos