[Complete response with tirabrutinib for relapsed and refractory Bing-Neel syndrome].
Rinsho Ketsueki
; 63(7): 770-775, 2022.
Article
en Ja
| MEDLINE
| ID: mdl-35922946
A 62-year-old female patient was diagnosed with Waldenstrom's macroglobulinemia/lymphoplasmacytic lymphoma (WM/LPL) 8 years ago, which was resolved with rituximab (R) monotherapy. Five years ago, she experienced numbness of the lower limbs, followed by diminished lower limb muscle strength and hearing disturbance. PET-CT scans showed accumulations along the peripheral nerves of the upper and lower limbs together with clonal B lymphocytes in the cerebrospinal fluid, thus a diagnosis of relapse with Bing-Neel syndrome (BNS). After a temporal remission by high-dose cytarabine or bendamustine plus R regimens as salvage treatments, WM/LPL recurred for the third time accompanied by gait disturbances due to muscle weakness and urinary retention. Thus, tirabrultinib was started as a subsequent therapy, which significantly improved the neurological condition together with abnormal findings of magnetic resonance imaging or cerebrospinal fluids. This case is valuable since few relapsed BNS was reported in the literature with successful tirabrutinib treatment.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Encefalopatías
/
Macroglobulinemia de Waldenström
/
Enfermedades Neurodegenerativas
Tipo de estudio:
Diagnostic_studies
Límite:
Female
/
Humans
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Middle aged
Idioma:
Ja
Revista:
Rinsho Ketsueki
Año:
2022
Tipo del documento:
Article
Pais de publicación:
Japón