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Regulation Mechanisms of Virulence Genes in Enterohemorrhagic Escherichia coli.
Gelalcha, Benti D; Brown, Selina M; Crocker, Hannah E; Agga, Getahun E; Kerro Dego, Oudessa.
Afiliación
  • Gelalcha BD; Department of Animal Science, The University of Tennessee Institute of Agriculture, Knoxville, Tennessee, USA.
  • Brown SM; Department of Animal Science, The University of Tennessee Institute of Agriculture, Knoxville, Tennessee, USA.
  • Crocker HE; Department of Animal Science, The University of Tennessee Institute of Agriculture, Knoxville, Tennessee, USA.
  • Agga GE; Food Animal Environmental Systems Research Unit, Agricultural Research Service, United States Department of Agriculture, Bowling Green, Kentucky, USA.
  • Kerro Dego O; Department of Animal Science, The University of Tennessee Institute of Agriculture, Knoxville, Tennessee, USA.
Foodborne Pathog Dis ; 19(9): 598-612, 2022 09.
Article en En | MEDLINE | ID: mdl-35921067
Enterohemorrhagic Escherichia coli (EHEC) is one of the most common E. coli pathotypes reported to cause several outbreaks of foodborne illnesses. EHEC is a zoonotic pathogen, and ruminants, especially cattle, are considered important reservoirs for the most common EHEC serotype, E. coli O157:H7. Humans are infected indirectly through the consumption of food (milk, meat, leafy vegetables, and fruits) and water contaminated by animal feces or direct contact with carrier animals or humans. E. coli O157:H7 is one of the most frequently reported causes of foodborne illnesses in developed countries. It employs two essential virulence mechanisms to trigger damage to the host. These are the development of attaching and effacing (AE) phenotypes on the intestinal mucosa of the host and the production of Shiga toxin (Stx) that causes hemorrhagic colitis and hemolytic uremic syndrome. The AE phenotype is controlled by the pathogenicity island, the locus of enterocyte effacement (LEE). The induction of both AE and Stx is under strict and highly complex regulatory mechanisms. Thus, a good understanding of these mechanisms, major proteins expressed, and environmental cues involved in the regulation of the expression of the virulence genes is vital to finding a method to control the colonization of reservoir hosts, especially cattle, and disease development in humans. This review is a concise account of the current state of knowledge of virulence gene regulation in the LEE-positive EHEC.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Escherichia coli O157 / Proteínas de Escherichia coli / Infecciones por Escherichia coli / Escherichia coli Enterohemorrágica / Enfermedades Transmitidas por los Alimentos Límite: Animals / Humans Idioma: En Revista: Foodborne Pathog Dis Asunto de la revista: CIENCIAS DA NUTRICAO / MICROBIOLOGIA / PARASITOLOGIA Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Escherichia coli O157 / Proteínas de Escherichia coli / Infecciones por Escherichia coli / Escherichia coli Enterohemorrágica / Enfermedades Transmitidas por los Alimentos Límite: Animals / Humans Idioma: En Revista: Foodborne Pathog Dis Asunto de la revista: CIENCIAS DA NUTRICAO / MICROBIOLOGIA / PARASITOLOGIA Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos