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Structural Connectivity and Emotion Recognition Impairment in Children and Adolescents with Chromosome 22q11.2 Deletion Syndrome.
Sanders, Ashley F P; Hobbs, Diana A; Knaus, Tracey A; Beaton, Elliott A.
Afiliación
  • Sanders AFP; Department of Psychology, University of New Orleans, 2000 Lakeshore Drive, New Orleans, LA, 70148, USA.
  • Hobbs DA; Department of Psychiatry, Washington University School of Medicine in St. Louis, St. Louis, MO, USA.
  • Knaus TA; Department of Psychology, University of New Orleans, 2000 Lakeshore Drive, New Orleans, LA, 70148, USA.
  • Beaton EA; Department of Radiology, Washington University School of Medicine in St. Louis, St. Louis, MO, USA.
J Autism Dev Disord ; 53(10): 4021-4034, 2023 Oct.
Article en En | MEDLINE | ID: mdl-35917023
Children with chromosome 22q11.2 deletion syndrome (22q11.2DS) exhibit impaired ability to process and understand emotions in others. We measured structural connectivity in children and adolescents with 22q11.2DS (n = 28) and healthy controls (n = 29). Compared to controls, those with 22q11.2DS had poorer social skills and more difficulty recognizing facial emotions. Children with 22q11.2DS also had higher fractional anisotropic diffusion in right amygdala to fusiform gyrus white matter pathways. Right amygdala to fusiform gyrus fractional anisotropy values partially mediated the relationship between 22q11.2DS and social skills, as well as the relationship between 22q11.2DS and emotion recognition accuracy. These findings provide insight into the neural origins of social skills deficits seen in 22q11.2DS and may serve as a biomarker for risk of future psychiatric problems.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Síndrome de DiGeorge / Sustancia Blanca / Trastorno del Espectro Autista Límite: Adolescent / Child / Humans Idioma: En Revista: J Autism Dev Disord Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Síndrome de DiGeorge / Sustancia Blanca / Trastorno del Espectro Autista Límite: Adolescent / Child / Humans Idioma: En Revista: J Autism Dev Disord Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos