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Clinicopathological features of appendiceal goblet cell adenocarcinoma in Japan: a multicenter retrospective study.
Shiota, Tetsuya; Murata, Kohei; Kishimoto, Mitsuo; Yao, Takashi; Noura, Shingo; Morita, Shunji; Akiyoshi, Takashi; Okamura, Shu; Imasato, Mitsunobu; Furuhata, Tomohisa; Suto, Takeshi; Takemasa, Ichiro; Shingai, Tatsushi; Ueda, Masami; Mizuno, Hitoshi; Hisamatsu, Yuichi; Takeda, Takashi; Fujii, Makoto; Kagawa, Yoshinori; Sugihara, Kenichi.
Afiliación
  • Shiota T; Department of Gastroenterological Surgery, Kobe City Nishi-Kobe Medical Center, Kobe, Japan. tetsuya_shiota@kcho.jp.
  • Murata K; Department of Gastroenterological Surgery, Kansai Rosai Hospital, Amagasaki, Japan.
  • Kishimoto M; Department of Pathology, Kyoto City Hospital, Kyoto, Japan.
  • Yao T; Department of Human Pathology, Juntendo University Graduate School of Medicine, Tokyo, Japan.
  • Noura S; Department of Surgery, Toyonaka Municipal Hospital, Osaka, Japan.
  • Morita S; Department of Surgery, Itami City Hospital, Osaka, Japan.
  • Akiyoshi T; Department of Gastroenterological Surgery, Cancer Institute Hospital of the Japanese Foundation for Cancer Research, Tokyo, Japan.
  • Okamura S; Department of Surgery, Suita Municipal Hospital, Osaka, Japan.
  • Imasato M; Department of Surgery, Osaka Police Hospital, Osaka, Japan.
  • Furuhata T; Department of Gastroenterological and General Surgery, St. Marianna University Toyoko Hospital, Kawasaki, Japan.
  • Suto T; Department of Gastroenterological Surgery, Yamagata Prefectural Central Hospital, Yamagata, Japan.
  • Takemasa I; Department of Surgery, Surgical Oncology, and Science, Sapporo Medical University School of Medicine, Sapporo, Japan.
  • Shingai T; Department of Gastroenterological Surgery, Saiseikai Senri Hospital, Osaka, Japan.
  • Ueda M; Department of Gastroenterological Surgery, Higashiosaka City Medical Center, Osaka, Japan.
  • Mizuno H; Department of Gastroenterological Surgery, Nippon Life Hospital, Osaka, Japan.
  • Hisamatsu Y; Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
  • Takeda T; Department of Gastroenterological Surgery, Minoh City Hospital, Osaka, Japan.
  • Fujii M; Division of Health Science, Graduate School of Medicine, Osaka University, Osaka, Japan.
  • Kagawa Y; Department of Gastroenterological Surgery, Osaka General Medical Center, Osaka, Japan.
  • Sugihara K; Tokyo Medical and Dental University, Tokyo, Japan.
Surg Today ; 53(2): 174-181, 2023 Feb.
Article en En | MEDLINE | ID: mdl-35913635
PURPOSE: In the 5th edition of the World Health Organization classification, appendiceal goblet cell adenocarcinoma (GCA) is categorized separately from neuroendocrine tumors and other appendiceal adenocarcinomas. We clarified the clinicopathological characteristics of Japanese appendiceal GCA. METHODS: We designed a retrospective multicenter cohort study and retrieved the data of patients with appendiceal neoplasms and histologically diagnosed appendiceal goblet cell carcinoid (GCC) treated from January 2000 to December 2017 in Japan. The available GCC slides were reviewed and diagnosed with a new grading system of GCA. RESULTS: A total of 922 patients from 43 institutions were enrolled; of these, 32 cases were patients with GCC (3.5%), and 20 cases were ultimately analyzed. The 5-year survival rate was 61.4% (95% confidence interval: 27.4-83.2), and the median survival time was 93.1 months. For peritoneal metastasis, regional lymph node metastasis was a significant factor (p = 0.04), and Grade 3 was a potential factor (p = 0.07). No peritoneal metastasis was observed in either T1/2 patients (n = 2) or Grade 1 patients (n = 4). We were unable to detect any significant factors associated with regional lymph node metastasis. CONCLUSION: For peritoneal metastasis, regional lymph node metastasis was a significant factor, and Grade 3 was a potential factor.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias del Apéndice / Tumor Carcinoide / Adenocarcinoma Tipo de estudio: Clinical_trials / Observational_studies / Risk_factors_studies Límite: Humans País/Región como asunto: Asia Idioma: En Revista: Surg Today Año: 2023 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Japón
Texto completo
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XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias del Apéndice / Tumor Carcinoide / Adenocarcinoma Tipo de estudio: Clinical_trials / Observational_studies / Risk_factors_studies Límite: Humans País/Región como asunto: Asia Idioma: En Revista: Surg Today Año: 2023 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Japón