A case of drug-induced acute liver failure caused by corticosteroids.
Clin J Gastroenterol
; 15(5): 946-952, 2022 Oct.
Article
en En
| MEDLINE
| ID: mdl-35913606
We report a 61-year-old man treated with betamethasone for sudden-onset deafness. Several days later, he had a temperature > 38 °C. He sought care at another hospital and was admitted based on abnormal liver function tests (aspartate aminotransferase [AST], 866 IU/L [normal < 31 IU/L] and alanine aminotransferase [ALT] 1524 IU/L [normal < 31 IU/L]). Liver function improved daily and the patient was discharged from the hospital after 5 days. Two days after discharge, he had a recurrent fever and liver dysfunction. After admission to our hospital, liver function improved spontaneously. A liver biopsy was performed, but a diagnosis was not established; however, a tentative diagnosis of antinuclear antibody-negative autoimmune hepatitis was made and the patient was started on prednisolone (30 mg). Two days later, he developed a fever and persistent liver dysfunction, thus the prednisolone was discontinued. The next day, the AST and ALT increased significantly (18,000 and 12,000 U/L, respectively). Because the level of consciousness was altered, plasma exchange was started for acute liver failure. After discontinuing the prednisolone, the hospital course was uneventful. Drug-induced liver injury due to corticosteroids is rare. Herein, we report a patient with acute liver failure who survived with timely treatment.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Fallo Hepático Agudo
/
Hepatitis Autoinmune
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Enfermedad Hepática Inducida por Sustancias y Drogas
Tipo de estudio:
Etiology_studies
Límite:
Humans
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Male
/
Middle aged
Idioma:
En
Revista:
Clin J Gastroenterol
Año:
2022
Tipo del documento:
Article
País de afiliación:
Japón
Pais de publicación:
Japón