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Proteomics Analysis of Antitumor Activity of Agrimonia pilosa Ledeb. in Human Oral Squamous Cell Carcinoma Cells.
Kim, Tae-Young; Koh, Kwang-Soo; Ju, Ji-Min; Kwak, Yeon-Ju; Bae, Soo-Kyung; Jang, Hye-Ock; Kim, Da-Sol.
Afiliación
  • Kim TY; Department of Dental Pharmacology, School of Dentistry, Pusan National University, 49, Busandaehak-ro, Yangsan-si 50612, Korea.
  • Koh KS; Department of Dental Pharmacology, School of Dentistry, Pusan National University, 49, Busandaehak-ro, Yangsan-si 50612, Korea.
  • Ju JM; Department of Dental Pharmacology, School of Dentistry, Pusan National University, 49, Busandaehak-ro, Yangsan-si 50612, Korea.
  • Kwak YJ; Education and Research Team for Life Science on Dentistry, Pusan National University, 49, Busandaehak-ro, Yangsan-si 50612, Korea.
  • Bae SK; Research Institute of GagopaHealing Food BioFarm, Agricultural Corporation Gagopa Healing Food Co., Changwon 51219, Korea.
  • Jang HO; Department of Dental Pharmacology, School of Dentistry, Pusan National University, 49, Busandaehak-ro, Yangsan-si 50612, Korea.
  • Kim DS; Dental and Life Science Institute, School of Dentistry, Pusan National University, 49, Busandaehak-ro, Yangsan-si 50612, Korea.
Curr Issues Mol Biol ; 44(8): 3324-3334, 2022 Jul 25.
Article en En | MEDLINE | ID: mdl-35892715
Oral cancer is a malignant neoplasm of oral cavity. It accounts for approximately 5% of all malignant tumors. Approximately 97% of all oral cancers are squamous cell carcinomas, followed by adenocarcinomas, and rarely malignant melanomas. It occurs particularly in males (twice as common in males than in females) of middle age (above 40 years). Agrimonia pilosa Ledeb. has traditionally been known for its effective antitumor activity and is currently used in China for cancer therapy. A. pilosa Ledeb. has been traditionally used for the treatment of abdominal pain, sore throat, headache, blood discharge, parasitic infections, and eczema in Korea and other Asian countries. Most studies on A. pilosa Ledeb. are related to the leaves and a few investigated the roots of the plant. However, detailed mechanisms of antitumor activity of A. pilosa Ledeb. have not been fully elucidated. Furthermore, to date, there have been no reports on the antitumor effect of A. pilosa Ledeb. in oral squamous cells. In this study, we used proteomic technology to observe changes in proteins related to anticancer activity of A. pilosa Ledeb. and identified target proteins among altered proteins to reveal the underlying mechanism of action.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Curr Issues Mol Biol Asunto de la revista: BIOLOGIA MOLECULAR Año: 2022 Tipo del documento: Article Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Curr Issues Mol Biol Asunto de la revista: BIOLOGIA MOLECULAR Año: 2022 Tipo del documento: Article Pais de publicación: Suiza