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Serum Markers Associated with Disease Severity in a Bosnian Hemorrhagic Fever with Renal Syndrome Cohort.
Noack, Danny; Travar, Maja; Mrdjen, Visnja; Voermans, Jolanda J C; van de Vijver, David; Molenkamp, Richard; Koopmans, Marion P G; Goeijenbier, Marco; Rockx, Barry.
Afiliación
  • Noack D; Department of Viroscience, Erasmus University Medical Center, 3015 GD Rotterdam, The Netherlands.
  • Travar M; Department for Clinical Microbiology, University Clinical Center of Republika Srpska, 78000 Banja Luka, Bosnia and Herzegovina.
  • Mrdjen V; Department for Microbiology and Immunology, Faculty of Medicine, University of Banja Luka, 78000 Banja Luka, Republika Srpska, Bosnia and Herzegovina.
  • Voermans JJC; Department for Clinical Microbiology, University Clinical Center of Republika Srpska, 78000 Banja Luka, Bosnia and Herzegovina.
  • van de Vijver D; Department for Microbiology and Immunology, Faculty of Medicine, University of Banja Luka, 78000 Banja Luka, Republika Srpska, Bosnia and Herzegovina.
  • Molenkamp R; Department of Viroscience, Erasmus University Medical Center, 3015 GD Rotterdam, The Netherlands.
  • Koopmans MPG; Department of Viroscience, Erasmus University Medical Center, 3015 GD Rotterdam, The Netherlands.
  • Goeijenbier M; Department of Viroscience, Erasmus University Medical Center, 3015 GD Rotterdam, The Netherlands.
  • Rockx B; Department of Viroscience, Erasmus University Medical Center, 3015 GD Rotterdam, The Netherlands.
Viruses ; 14(7)2022 06 24.
Article en En | MEDLINE | ID: mdl-35891358
Puumala orthohantavirus (PUUV) is endemic in Europe and can cause hemorrhagic fever with renal syndrome (nephropathia epidemica). Disease features include fever, thrombocytopenia, and acute kidney injury (AKI). This retrospective cohort study of forty PUUV patients aims to characterize associations of serum immunological, hemostatic or kidney injury markers to disease severity. While interleukin-18 (IL-18) was significantly increased in severely thrombocytopenic patients (<100 × 109 platelets/L) compared to patients with higher platelet counts, RANTES was significantly decreased in these patients. These data suggest that patients with significant thrombocytopenia might have experienced pronounced Th1 immune responses. When kidney dysfunction was used as the primary disease outcome, recently identified AKI biomarkers (Cystatin C, insulin-like growth factor-binding protein 7, Nephrin, and trefoil factor 3) were significantly upregulated in patients with severe PUUV infection, defined as the estimated glomerular filtration rate (eGFR) below 30 m/min/1.73 m2. The increased expression of these markers specifically indicates pathology in glomeruli and proximal tubuli. Furthermore, E-selectin was significantly higher while interferon gamma-induced protein 10 (IP-10) was significantly lower in PUUV patients with more severe kidney dysfunction compared to patients with higher eGFR-values. Increased E-selectin illustrates the central role of endothelial cell activation, whereas decreased IP-10 could indicate a less important role of this cytokine in the pathogenesis of kidney dysfunction.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trombocitopenia / Virus Puumala / Lesión Renal Aguda / Fiebre Hemorrágica con Síndrome Renal Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: Viruses Año: 2022 Tipo del documento: Article País de afiliación: Países Bajos Pais de publicación: Suiza
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trombocitopenia / Virus Puumala / Lesión Renal Aguda / Fiebre Hemorrágica con Síndrome Renal Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: Viruses Año: 2022 Tipo del documento: Article País de afiliación: Países Bajos Pais de publicación: Suiza