A Physiologically Based Pharmacokinetic and Pharmacodynamic Model of the CYP3A4 Substrate Felodipine for Drug-Drug Interaction Modeling.

Fuhr, Laura Maria; Marok, Fatima Zahra; Mees, Maximilian; Mahfoud, Felix; Selzer, Dominik; Lehr, Thorsten

Fuhr, Laura Maria; Marok, Fatima Zahra; Mees, Maximilian; Mahfoud, Felix; Selzer, Dominik; Lehr, Thorsten.

Afiliación

Fuhr LM; Department of Clinical Pharmacy, Saarland University, 66123 Saarbrücken, Germany.
Marok FZ; Department of Clinical Pharmacy, Saarland University, 66123 Saarbrücken, Germany.
Mees M; Department of Clinical Pharmacy, Saarland University, 66123 Saarbrücken, Germany.
Mahfoud F; Department of Internal Medicine III (Cardiology, Angiology, Intensive Care Medicine), Saarland University Medical Center and Saarland University Faculty of Medicine, 66421 Homburg, Germany.
Selzer D; Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Lehr T; Department of Clinical Pharmacy, Saarland University, 66123 Saarbrücken, Germany.

Pharmaceutics ; 14(7)2022 Jul 15.

Article en En | MEDLINE | ID: mdl-35890369

Palabras clave

cytochrome P450 3A4 (CYP3A4); drugdrug interactions (DDIs); felodipine; pharmacodynamics; physiologically based pharmacokinetic (PBPK) modeling

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Prognostic_studies Idioma: En Revista: Pharmaceutics Año: 2022 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Suiza

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