Activation of a Bacterial Mechanosensitive Channel, MscL, Underlies the Membrane Permeabilization of Dual-Targeting Antibacterial Compounds.

Wray, Robin; Wang, Junmei; Blount, Paul; Iscla, Irene

Wray, Robin; Wang, Junmei; Blount, Paul; Iscla, Irene.

Afiliación

Wray R; Department of Physiology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX 75390, USA.
Wang J; Computational Chemical Genomics Screening Center, Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Pittsburg, PA 15261, USA.
Blount P; Department of Physiology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX 75390, USA.
Iscla I; Department of Physiology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX 75390, USA.

Antibiotics (Basel) ; 11(7)2022 Jul 19.

Article en En | MEDLINE | ID: mdl-35884223

Palabras clave

antibiotic resistance; bacterial channels; bacterial drug target; druggable target; dual mechanism antibiotics

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Antibiotics (Basel) Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Suiza

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