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Factors Involved in Endothelial Dysfunction Related to Angiogenic Disbalance and Oxidative Stress, in Women at High Risk of Term Pre-Eclampsia.
Santoyo, Jean Michell; Noguera, José Antonio; Avilés, Francisco; Delgado, Juan Luis; de Paco-Matallana, Catalina; Pérez, Virginia; Hernández, Isabel.
Afiliación
  • Santoyo JM; Physiology Department, Institute of Biomedical Research (IMIB-Arrixaca), Universidad de Murcia, 30120 Murcia, Spain.
  • Noguera JA; Institute of Biomedical Research (IMIB-Arrixaca), Hospital Clínico Universitario Virgen de la Arrixaca, 30120 Murcia, Spain.
  • Avilés F; Institute of Biomedical Research (IMIB-Arrixaca), Hospital Clínico Universitario Virgen de la Arrixaca, 30120 Murcia, Spain.
  • Delgado JL; Institute of Biomedical Research (IMIB-Arrixaca), Hospital Clínico Universitario Virgen de la Arrixaca, 30120 Murcia, Spain.
  • de Paco-Matallana C; Institute of Biomedical Research (IMIB-Arrixaca), Hospital Clínico Universitario Virgen de la Arrixaca, 30120 Murcia, Spain.
  • Pérez V; Departamento de Ciencias Sociosanitarias, Institute of Biomedical Research (IMIB-Arrixaca), Universidad de Murcia, 30120 Murcia, Spain.
  • Hernández I; Physiology Department, Institute of Biomedical Research (IMIB-Arrixaca), Universidad de Murcia, 30120 Murcia, Spain.
Antioxidants (Basel) ; 11(7)2022 Jul 21.
Article en En | MEDLINE | ID: mdl-35883900
Oxidative and inflammatory stress, angiogenic imbalance, and endothelial dysfunction are pathophysiological mechanisms occurring in pre-eclampsia (PE) that may persist over time and predispose women to a higher risk of cardiovascular disease (CVD) in the future. However, there is little evidence on the vascular function of women at risk of PE who have not developed the disease. The main objective of this research is to study factors and biomarkers involved in endothelial dysfunction related to oxidative stress, angiogenic disbalance, and inflammation in women at high risk of term PE who do not develop the disease. An observational, analytical, retrospective, and descriptive study was carried out in a selected sample of 68 high-risk and 57 non-risk of term PE participants in the STATIN study (FFIS/2016/02/ST EUDRACT No: 2016-005206-19). A significant increase in mean arterial pressure (MAP) levels and oxidative stress biomarkers (uric acid, homocysteine, and total serum antioxidant capacity) was found. Biomarkers of inflammation (interleukin-6 and growth differentiation factor 15) and endothelial function (asymmetric dimethylarginine) were significantly elevated in the group at risk of pre-eclampsia. A significative dependence relationship was also established between MAP and interleukin-6 and uric acid. These results suggest that women at high risk of term PE may represent pregnancies with pre-existing maternal risk factors for CVD, manifested by the own cardiovascular overload of pregnancy. A better understanding of maternal cardiovascular function in pregnancy would allow the improved prediction of CVD late in life in women.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Etiology_studies / Prognostic_studies / Risk_factors_studies Idioma: En Revista: Antioxidants (Basel) Año: 2022 Tipo del documento: Article País de afiliación: España Pais de publicación: Suiza
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Etiology_studies / Prognostic_studies / Risk_factors_studies Idioma: En Revista: Antioxidants (Basel) Año: 2022 Tipo del documento: Article País de afiliación: España Pais de publicación: Suiza