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Timing evolution of lobular breast cancer through phylogenetic analysis.
Fimereli, Danai; Venet, David; Rediti, Mattia; Boeckx, Bram; Maetens, Marion; Majjaj, Samira; Rouas, Ghizlane; Marchio, Caterina; Bertucci, Francois; Mariani, Odette; Capra, Maria; Bonizzi, Giuseppina; Contaldo, Federica; Galant, Christine; Van den Eynden, Gert; Salgado, Roberto; Biganzoli, Elia; Vincent-Salomon, Anne; Pruneri, Giancarlo; Larsimont, Denis; Lambrechts, Diether; Desmedt, Christine; Brown, David N; Rothé, Françoise; Sotiriou, Christos.
Afiliación
  • Fimereli D; J.-C. Heuson Breast Cancer Translational Research Laboratory, Institut Jules Bordet, Université Libre de Bruxelles, Brussels, Belgium.
  • Venet D; J.-C. Heuson Breast Cancer Translational Research Laboratory, Institut Jules Bordet, Université Libre de Bruxelles, Brussels, Belgium.
  • Rediti M; J.-C. Heuson Breast Cancer Translational Research Laboratory, Institut Jules Bordet, Université Libre de Bruxelles, Brussels, Belgium.
  • Boeckx B; Laboratory of Translational Genetics, VIB Center for Cancer Biology, Leuven, Belgium; Laboratory of Translational Genetics, Department of Human Genetics, KU Leuven, Leuven, Belgium.
  • Maetens M; J.-C. Heuson Breast Cancer Translational Research Laboratory, Institut Jules Bordet, Université Libre de Bruxelles, Brussels, Belgium; Laboratory for Translational Breast Cancer Research, Department of Oncology, KU Leuven, Leuven, Belgium.
  • Majjaj S; J.-C. Heuson Breast Cancer Translational Research Laboratory, Institut Jules Bordet, Université Libre de Bruxelles, Brussels, Belgium.
  • Rouas G; J.-C. Heuson Breast Cancer Translational Research Laboratory, Institut Jules Bordet, Université Libre de Bruxelles, Brussels, Belgium.
  • Marchio C; Department of Medical Sciences, University of Turin, Turin, Italy; FPO-IRCCS Candiolo Cancer Institute, Candiolo, Italy.
  • Bertucci F; Predictive Oncology Laboratory, Institut Paoli-Calmettes, CRCM, INSERM U1068, CNRS UMR7258, Aix-Marseille Université Marseille, France.
  • Mariani O; Department of Pathology, Institut Curie, Paris Sciences Lettres Research University, Paris, France.
  • Capra M; Biobank for Translational and Digital Medicine, IEO, European Institute of Oncology IRCCS, Milan, Italy.
  • Bonizzi G; Biobank for Translational and Digital Medicine, IEO, European Institute of Oncology IRCCS, Milan, Italy.
  • Contaldo F; Biobank for Translational and Digital Medicine, IEO, European Institute of Oncology IRCCS, Milan, Italy.
  • Galant C; Department of Pathology, Cliniques Universitaires Saint Luc, Brussels, Belgium; IREC, Université Catholique de Louvain, Brussels, Belgium.
  • Van den Eynden G; Department of Pathology, Sint Augustinus, Wilrijk, Belgium.
  • Salgado R; Department of Pathology, GZA-ZNA Hospitals, Antwerp, Belgium; Division of Research, Peter Mac Callum Cancer Centre, Melbourne, Australia.
  • Biganzoli E; Department of Biomedical and Clinical Sciences (DIBIC) "L. Sacco" & DSRC, LITA Vialba campus, University of Milan, Milan, Italy.
  • Vincent-Salomon A; Department of Pathology, Institut Curie, Paris Sciences Lettres Research University, Paris, France.
  • Pruneri G; Division of Pathology, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy; School of Medicine, University of Milan, Milano, Milan, Italy.
  • Larsimont D; Department of Pathology, Institut Jules Bordet, Brussels, Belgium.
  • Lambrechts D; Laboratory of Translational Genetics, VIB Center for Cancer Biology, Leuven, Belgium; Laboratory of Translational Genetics, Department of Human Genetics, KU Leuven, Leuven, Belgium.
  • Desmedt C; Laboratory for Translational Breast Cancer Research, Department of Oncology, KU Leuven, Leuven, Belgium.
  • Brown DN; J.-C. Heuson Breast Cancer Translational Research Laboratory, Institut Jules Bordet, Université Libre de Bruxelles, Brussels, Belgium; Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
  • Rothé F; J.-C. Heuson Breast Cancer Translational Research Laboratory, Institut Jules Bordet, Université Libre de Bruxelles, Brussels, Belgium.
  • Sotiriou C; J.-C. Heuson Breast Cancer Translational Research Laboratory, Institut Jules Bordet, Université Libre de Bruxelles, Brussels, Belgium. Electronic address: christos.sotiriou@bordet.be.
EBioMedicine ; 82: 104169, 2022 Aug.
Article en En | MEDLINE | ID: mdl-35882101
BACKGROUND: Late distant recurrence is a challenge for the treatment of invasive lobular carcinoma (ILC) of the breast. Despite in-depth characterisation of primary ILC, the molecular landscape of metastatic ILC is still only partially understood. METHODS: We retrospectively identified 38 ILC patients from the tissue banks of six European institutions. DNA extracted from patient matched primary and metastatic FFPE tissue blocks was whole genome sequenced to compute somatic copy number aberrations. This, in turn, was used to infer the evolutionary history of these patients. FINDINGS: The data show different metastatic seeding patterns, with both an early and late divergence of the metastatic lineage observed in ILC. Additionally, cascading dissemination from a metastatic precursor was a dominant rule. Alterations in key cancer driver genes, such as TP53 or CCND1, were acquired early while additional aberrations were present only in the metastatic branch. In about 30% of the patients, the metastatic lineage harboured less aberrations than the primary tumour suggesting a period of tumour dormancy or prolonged adaptation at the distant site. This phenomenon was mostly observed in tumours from de novo metastatic patients. INTERPRETATION: Our results provide insights into ILC evolution and offer potential paths for optimised ILC care. FUNDING: This work has received financial support from Les Amis de l'Institut Bordet, MEDIC, the Breast Cancer Research Foundation (BCRF) and the Belgian Fonds National de la Recherche Scientifique (F.R.S-FNRS).
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Mama / Carcinoma Lobular Tipo de estudio: Observational_studies / Prognostic_studies Límite: Female / Humans Idioma: En Revista: EBioMedicine Año: 2022 Tipo del documento: Article País de afiliación: Bélgica Pais de publicación: Países Bajos
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Mama / Carcinoma Lobular Tipo de estudio: Observational_studies / Prognostic_studies Límite: Female / Humans Idioma: En Revista: EBioMedicine Año: 2022 Tipo del documento: Article País de afiliación: Bélgica Pais de publicación: Países Bajos