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Fluid shear stress induces cell migration via RhoA-YAP1-autophagy pathway in liver cancer stem cells.
Yan, Zhiping; Guo, Danfeng; Tao, Ruolin; Yu, Xiao; Zhang, Jiacheng; He, Yuting; Zhang, Jiakai; Li, Jie; Zhang, Shuijun; Guo, Wenzhi.
Afiliación
  • Yan Z; Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China.
  • Guo D; Henan Liver Transplantation Center, Zhengzhou, Henan Province, 450052, China.
  • Tao R; Henan Research Center for Organ Transplantation, Zhengzhou, 450052, China.
  • Yu X; Henan Key Laboratory of Digestive Organ Transplantation, Zhengzhou, 450052, China.
  • Zhang J; Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China.
  • He Y; Henan Liver Transplantation Center, Zhengzhou, Henan Province, 450052, China.
  • Zhang J; Henan Research Center for Organ Transplantation, Zhengzhou, 450052, China.
  • Li J; Henan Key Laboratory of Digestive Organ Transplantation, Zhengzhou, 450052, China.
  • Zhang S; Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China.
  • Guo W; Henan Liver Transplantation Center, Zhengzhou, Henan Province, 450052, China.
Cell Adh Migr ; 16(1): 94-106, 2022 12.
Article en En | MEDLINE | ID: mdl-35880618
Fluid shear stress (FSS) regulates the metastasis of hepatocellular carcinoma (HCC), but the role of the RhoA-YAP1-autophagy pathway in HCC remains unclear. Due to the core role of liver cancer stem cells (LCSCs) in HCC metastasis and recurrence, we explored the RhoA-YAP1-autophagy pathway in LCSCs under FSS. Our results indicate that LCSCs have stronger proliferation and cell spheroidization abilities. FSS (1 dyn/cm2) upregulated the migration of LCSCs and autophagy protein markers, inducing LC3B aggregation and autophagosome formation in LCSCs. Mechanistically, FSS promoted YAP1 dephosphorylation and transport to the nucleus, which is mediated by RhoA, inducing autophagy. Finally, inhibition of autophagy suppressed cell migration in LCSCs under FSS. In conclusion, FSS promoted the migration of LCSCs via the RhoA-YAP1-autophagy pathway.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Carcinoma Hepatocelular / Neoplasias Hepáticas Límite: Humans Idioma: En Revista: Cell Adh Migr Año: 2022 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos
Texto completo
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PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Carcinoma Hepatocelular / Neoplasias Hepáticas Límite: Humans Idioma: En Revista: Cell Adh Migr Año: 2022 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos