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Poly-γ-glutamic acid coating polymeric nanoparticles enhance renal drug distribution and cellular uptake for diabetic nephropathy therapy.
Wang, Qili; Han, Shunping; Zhu, Yongqin; Wang, Guowei; Chen, Danfei.
Afiliación
  • Wang Q; Department of Pediatrics, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Traditional Chinses Medicine), Zhejiang Chinese Medical University, Hangzhou, China.
  • Han S; College of Pharmaceutical Science, Zhejiang Chinese Medical University, Hangzhou, China.
  • Zhu Y; Department of Pediatrics, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Traditional Chinses Medicine), Zhejiang Chinese Medical University, Hangzhou, China.
  • Wang G; Hangzhou Global Scientific and Technological Innovation Center, Zhejiang University, Hangzhou, China.
  • Chen D; Department of Pediatrics, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Traditional Chinses Medicine), Zhejiang Chinese Medical University, Hangzhou, China.
J Drug Target ; 31(1): 89-99, 2023 01.
Article en En | MEDLINE | ID: mdl-35880399
Poor drug distribution and inefficient renal cellular uptake are the major barriers diminishing the efficacy of nanoparticles in renal targeted therapy. We designed the rhein (RH)-loaded poly-γ-glutamic acid (PGA)-coated polycaprolactone-polyethyleneimine nanoparticles (RGPP) to enhance renal drug distribution and cellular uptake via PGA-mediated receptor-ligand interaction with γ-glutamyltranspeptidase (GGT) expressed highly in the kidney. PGA coating not only ensured the stability, sustained drug release, and biocompatibility of RGPP, but also promoted renal cellular uptake via binding with the GGT on the renal cells. Following intravenous administration, PGA coating protects RGPP from recognition by the reticuloendothelial system, resulting in prolonged blood circulation. RGPP enables targeted RH accumulation in the kidneys of streptozotocin-induced diabetic nephropathy (DN) mice, resulting in significant recovery of renal physiological function. The PGA coating strategy opens a new avenue for the management of renal diseases using nanomedicine.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Diabetes Mellitus / Nefropatías Diabéticas / Nanopartículas Límite: Animals Idioma: En Revista: J Drug Target Asunto de la revista: FARMACOLOGIA Año: 2023 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Diabetes Mellitus / Nefropatías Diabéticas / Nanopartículas Límite: Animals Idioma: En Revista: J Drug Target Asunto de la revista: FARMACOLOGIA Año: 2023 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido