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In vitro cytotoxic activity of Cuphea ingrata Cham. & Schltdl. extracts related to the oenothein B content.
Sobolewska, Danuta; Galanty, Agnieszka; Granica, Sebastian; Podolak, Irma; Olszewska, Monika Anna; Owczarek, Aleksandra; Paulino, Niraldo; Michalska, Klaudia.
Afiliación
  • Sobolewska D; Department of Pharmacognosy, Jagiellonian University, Medical College, Kraków, Poland.
  • Galanty A; Department of Pharmacognosy, Jagiellonian University, Medical College, Kraków, Poland.
  • Granica S; Centre for Preclinical Research, Department of Pharmacognosy and Molecular Basis of Phytotherapy, Faculty of Pharmacy Medical University of Warsaw, Microbiota Lab, Warsaw, Poland.
  • Podolak I; Department of Pharmacognosy, Jagiellonian University, Medical College, Kraków, Poland.
  • Olszewska MA; Department of Pharmacognosy, Faculty of Pharmacy, Medical University of Lodz, Lodz, Poland.
  • Owczarek A; Department of Pharmacognosy, Faculty of Pharmacy, Medical University of Lodz, Lodz, Poland.
  • Paulino N; Medical Lex Ltda, Florianópolis, SC, Brazil.
  • Michalska K; Maj Institute of Pharmacology, Polish Academy of Sciences, Department of Phytochemistry, Kraków, Poland.
Nat Prod Res ; 37(10): 1693-1697, 2023 May.
Article en En | MEDLINE | ID: mdl-35876228
Cuphea ingrata is a traditional medicinal plant species of the Lythraceae family. This work reports on the cytotoxic activity of the methanolic extract from the aerial parts of C. ingrata and the n-butanol and ethyl acetate fractions against human skin and prostate cancer cells. The selectivity of action was tested in normal skin keratinocytes HaCaT and prostate epithelial cells PNT2. The ethyl acetate fraction showed the highest activity in all three human skin cancer cell lines: A375, HTB-140, WM793, with IC50 = 15.90; 3.40; 18.75 µg/mL, respectively. To obtain comparative information on the chemical composition, a quantitative analysis of oenothein B was performed using the UHPLC-PDA method. An analysis of its cytotoxic activity was also carried out.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Plantas Medicinales / Cuphea / Antineoplásicos Límite: Humans / Male Idioma: En Revista: Nat Prod Res Año: 2023 Tipo del documento: Article País de afiliación: Polonia Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Plantas Medicinales / Cuphea / Antineoplásicos Límite: Humans / Male Idioma: En Revista: Nat Prod Res Año: 2023 Tipo del documento: Article País de afiliación: Polonia Pais de publicación: Reino Unido