Relationship between zinc-related nutritional status and the progression of multiple sclerosis.
Mult Scler Relat Disord
; 66: 104063, 2022 Oct.
Article
en En
| MEDLINE
| ID: mdl-35872505
BACKGROUND: Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system. OBJECTIVE: To investigate plasma and erythrocyte zinc status and its relationship to MS. METHODS: Cross-sectional study, including 98 participants, distributed in groups: case (MS, n = 49), diagnosed with MS and control (n = 49), matched by age and sex with the case group. Zinc was analyzed by flame atomic absorption spectrophotometry, and superoxide dismutase (SOD) activity by spectrophotometry. RESULTS: Mean plasma zinc was 94.6 (22.1) µg/dL for MS patients and 81.5 (31.3) µg/dL for control group, with statistical difference (p = 0.023). The mean erythrocyte zinc was 83.6 (41.6) µg/gHb for case group and 72.6 (31.5) µg/gHb for control. Erythrocyte SOD activity was above reference values, significantly different for MS patients (p = 0.003). There was a significant direct correlation between erythrocyte zinc and SOD (r = 0.835; p < 0.001). SOD showed inverse correlation with MS outbreaks (r = -0.317; p = 0.027). CONCLUSION: Patients with MS have normal plasma and elevated erythrocyte zinc. Erythrocyte zinc showed positive correlation with SOD, which correlated inversely to outbreaks.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Oxibato de Sodio
/
Esclerosis Múltiple
Tipo de estudio:
Observational_studies
/
Prevalence_studies
/
Risk_factors_studies
Límite:
Humans
Idioma:
En
Revista:
Mult Scler Relat Disord
Año:
2022
Tipo del documento:
Article
País de afiliación:
Brasil
Pais de publicación:
Países Bajos