Your browser doesn't support javascript.
loading
Relationship between zinc-related nutritional status and the progression of multiple sclerosis.
Castro, Ádila da Silva; Albuquerque, Larissa da Silva; Melo, Maria Luísa Pereira de; D'Almeida, José Artur Costa; Braga, Ribanna Aparecida Marques; Assis, Renata Carmo de; Marreiro, Dilina do Nascimento; Matos, Wladiana Oliveira; Maia, Carla Soraya Costa.
Afiliación
  • Castro ÁDS; State University of Ceara, Av. Doutor Silas Munguba, 1700, Itaperi Campus. Zip code 60741-000, Fortaleza- Ceara, Brazil; University of Fortaleza. Av. Washington Soares, Zip code 1321, Edson Queiroz, Fortaleza, State of Ceara 60811-905, Brazil.
  • Albuquerque LDS; State University of Ceara, Av. Doutor Silas Munguba, 1700, Itaperi Campus. Zip code 60741-000, Fortaleza- Ceara, Brazil; University of Fortaleza. Av. Washington Soares, Zip code 1321, Edson Queiroz, Fortaleza, State of Ceara 60811-905, Brazil.
  • Melo MLP; State University of Ceara, Av. Doutor Silas Munguba, 1700, Itaperi Campus. Zip code 60741-000, Fortaleza- Ceara, Brazil; Multiple Sclerosis Treatment Center - Fortaleza General Hospital. Zip code 900, Ávila Goulart Street, Papicu, Fortaleza, State of Ceara 60150-160, Brazil.
  • D'Almeida JAC; Multiple Sclerosis Treatment Center - Fortaleza General Hospital. Zip code 900, Ávila Goulart Street, Papicu, Fortaleza, State of Ceara 60150-160, Brazil.
  • Braga RAM; State University of Ceara, Av. Doutor Silas Munguba, 1700, Itaperi Campus. Zip code 60741-000, Fortaleza- Ceara, Brazil.
  • Assis RC; State University of Ceara, Av. Doutor Silas Munguba, 1700, Itaperi Campus. Zip code 60741-000, Fortaleza- Ceara, Brazil.
  • Marreiro DDN; Federal University of Piaui. Ininga, Ministro Petrônio Portella Campus, Teresina, State of Piaui 64049-550, Brazil.
  • Matos WO; Federal University of Ceara. Av Mister Hull, s/n, Pici Campus, Fortaleza, State of Ceara 60455-760, Brazil.
  • Maia CSC; State University of Ceara, Av. Doutor Silas Munguba, 1700, Itaperi Campus. Zip code 60741-000, Fortaleza- Ceara, Brazil. Electronic address: carla.maia@uece.br.
Mult Scler Relat Disord ; 66: 104063, 2022 Oct.
Article en En | MEDLINE | ID: mdl-35872505
BACKGROUND: Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system. OBJECTIVE: To investigate plasma and erythrocyte zinc status and its relationship to MS. METHODS: Cross-sectional study, including 98 participants, distributed in groups: case (MS, n = 49), diagnosed with MS and control (n = 49), matched by age and sex with the case group. Zinc was analyzed by flame atomic absorption spectrophotometry, and superoxide dismutase (SOD) activity by spectrophotometry. RESULTS: Mean plasma zinc was 94.6 (22.1) µg/dL for MS patients and 81.5 (31.3) µg/dL for control group, with statistical difference (p = 0.023). The mean erythrocyte zinc was 83.6 (41.6) µg/gHb for case group and 72.6 (31.5) µg/gHb for control. Erythrocyte SOD activity was above reference values, significantly different for MS patients (p = 0.003). There was a significant direct correlation between erythrocyte zinc and SOD (r = 0.835; p < 0.001). SOD showed inverse correlation with MS outbreaks (r = -0.317; p = 0.027). CONCLUSION: Patients with MS have normal plasma and elevated erythrocyte zinc. Erythrocyte zinc showed positive correlation with SOD, which correlated inversely to outbreaks.
Asunto(s)
Palabras clave

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Oxibato de Sodio / Esclerosis Múltiple Tipo de estudio: Observational_studies / Prevalence_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: Mult Scler Relat Disord Año: 2022 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Países Bajos

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Oxibato de Sodio / Esclerosis Múltiple Tipo de estudio: Observational_studies / Prevalence_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: Mult Scler Relat Disord Año: 2022 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Países Bajos