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Serum protein and electrolyte imbalances are associated with chemotherapy induced neutropenia.
Abbasi, Benazir; Hayat, Amjad; Lyons, Mark; Gupta, Ananya; Gupta, Sanjeev.
Afiliación
  • Abbasi B; Discipline of Pathology, School of Medicine, Clinical Science Institute, National University of Ireland Galway, Galway, H91 YR71, Ireland.
  • Hayat A; Haematology Department, University Hospital Galway, Saolta University Health Care Group, Galway, H91 YR71, Ireland.
  • Lyons M; Haematology Department, University Hospital Galway, Saolta University Health Care Group, Galway, H91 YR71, Ireland.
  • Gupta A; Discipline of Physiology, School of Medicine, National University of Ireland Galway, Galway, H91 W5P7, Ireland.
  • Gupta S; Discipline of Pathology, School of Medicine, Clinical Science Institute, National University of Ireland Galway, Galway, H91 YR71, Ireland.
Heliyon ; 8(7): e09949, 2022 Jul.
Article en En | MEDLINE | ID: mdl-35865973
Introduction: Cancer and its treatment using various chemotherapeutic agents can have many adverse side effects. These side effects often result in significant changes in haematological and biochemical composition of blood. As a result, the regular monitoring of serum biochemical and haematological changes plays an important role in management of disease. The present study aimed to determine the relationship between haematological and biochemical changes in neutropenic cancer patients following chemotherapy. Specifically we evaluated the association between neutrophil count and serum proteins and electrolytes. Methods: For this purpose we analysed retrospectively collected laboratory results from two independent patient cohorts. Each cohort was divided into a control group consisting of patients with normal haematological parameters and a study group which included patients with reduced neutrophil counts. Neutropenic patients (study group) were cancer patients on chemotherapy. Results and conclusion: Blood samples of cancer patients in study group showed reduction in haemoglobin, neutrophils and platelets. Neutropenic group showed a significant reduction in serum albumin, total protein, calcium, and potassium. Our results show that patients with severe neutropenia had pronounced changes in serum protein and electrolytes and increased incidence of abnormal serum protein and electrolyte level. The changes in the neutrophil counts showed a positive correlation with the changes in serum protein and electrolyte levels. A similar trend was seen in both the patient cohorts: the discovery set (176 patients) and the validation set (200 patients). Taken together our results suggest that chemotherapy-induced neutropenia is associated with dysregulation in haemoglobin, platelets, serum proteins and electrolytes.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Risk_factors_studies Idioma: En Revista: Heliyon Año: 2022 Tipo del documento: Article País de afiliación: Irlanda Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Risk_factors_studies Idioma: En Revista: Heliyon Año: 2022 Tipo del documento: Article País de afiliación: Irlanda Pais de publicación: Reino Unido