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Cs2CO3 catalyzed direct aza-Michael addition of azoles to α,ß-unsaturated malonates.
Jiang, Zi-Yu; Huang, Zhe-Yao; Yang, Hong; Zhou, Lin; Li, Qing-Han; Zhao, Zhi-Gang.
Afiliación
  • Jiang ZY; Key Laboratory of General Chemistry of the National Ethnic Affairs Commission, College of Chemistry and Environment, Southwest Minzu University Chengdu 610041 P. R. China zhoulin@swun.edu.cn.
  • Huang ZY; Key Laboratory of General Chemistry of the National Ethnic Affairs Commission, College of Chemistry and Environment, Southwest Minzu University Chengdu 610041 P. R. China zhoulin@swun.edu.cn.
  • Yang H; Key Laboratory of General Chemistry of the National Ethnic Affairs Commission, College of Chemistry and Environment, Southwest Minzu University Chengdu 610041 P. R. China zhoulin@swun.edu.cn.
  • Zhou L; Key Laboratory of General Chemistry of the National Ethnic Affairs Commission, College of Chemistry and Environment, Southwest Minzu University Chengdu 610041 P. R. China zhoulin@swun.edu.cn.
  • Li QH; Key Laboratory of General Chemistry of the National Ethnic Affairs Commission, College of Chemistry and Environment, Southwest Minzu University Chengdu 610041 P. R. China zhoulin@swun.edu.cn.
  • Zhao ZG; Key Laboratory of General Chemistry of the National Ethnic Affairs Commission, College of Chemistry and Environment, Southwest Minzu University Chengdu 610041 P. R. China zhoulin@swun.edu.cn.
RSC Adv ; 12(30): 19265-19269, 2022 Jun 29.
Article en En | MEDLINE | ID: mdl-35865588
A highly efficient method for the synthesis of azole derivatives via a direct aza-Michael addition of azoles to α,ß-unsaturated malonates using Cs2CO3 as a catalyst, has been successfully developed. A series of azole derivatives have been obtained in up to 94% yield and the reaction could be amplified to gram scale in excellent yield in the presence of 10 mol% of Cs2CO3.

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: RSC Adv Año: 2022 Tipo del documento: Article Pais de publicación: Reino Unido

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: RSC Adv Año: 2022 Tipo del documento: Article Pais de publicación: Reino Unido