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Cytotoxic abietane diterpenoids from Salvia leriifolia Benth.
Sarhadi, Elham; Nejad Ebrahimi, Samad; Hadjiakhoondi, Abbas; Abbas-Mohammadi, Mahdi; Manayi, Azadeh; Parisi, Valentina; Pessolano, Emanuela; Petrella, Antonello; De Tommasi, Nunziatina.
Afiliación
  • Sarhadi E; Medicinal Plants Research Centr, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
  • Nejad Ebrahimi S; Department of Phytochemistry, Medicinal Plants and Drugs Research Institute, Shahid Beheshti University, Tehran, Iran. Electronic address: s_ebrahimi@sbu.ac.ir.
  • Hadjiakhoondi A; Medicinal Plants Research Centr, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran; Department of Pharmacognosy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
  • Abbas-Mohammadi M; Department of Organic Chemistry, Faculty of Chemistry, University of Kashan, Kashan, Iran.
  • Manayi A; Medicinal Plants Research Centr, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
  • Parisi V; Dipartimento di Farmacia, Università Degli Studi di Salerno, Via Giovanni Paolo II N° 132, 84084, Fisciano, SA, Italy.
  • Pessolano E; Dipartimento di Farmacia, Università Degli Studi di Salerno, Via Giovanni Paolo II N° 132, 84084, Fisciano, SA, Italy.
  • Petrella A; Dipartimento di Farmacia, Università Degli Studi di Salerno, Via Giovanni Paolo II N° 132, 84084, Fisciano, SA, Italy.
  • De Tommasi N; Dipartimento di Farmacia, Università Degli Studi di Salerno, Via Giovanni Paolo II N° 132, 84084, Fisciano, SA, Italy. Electronic address: detommasi@unisa.it.
Phytochemistry ; 202: 113310, 2022 Oct.
Article en En | MEDLINE | ID: mdl-35863476
The Phytochemical profiling of the root extract of Salvia leriifolia, an endemic plant of Iran, was investigated and 16 abietane diterpenes were isolated, and three were original compounds. 1D and 2D NMR and HRMS performed structural elucidation. The absolute configuration of the previously unreported compounds was determined by circular dichroism (ECD). The cytotoxicity of the isolated compounds was investigated against AGS, MIA PaCa-2, HeLa, and MCF-7 cell lines by the MTT assay. The known diterpene pisiferal possesses high cytotoxicity against all investigated cell lines at a concentration between 9.3 ± 0.6 and 14.38 ± 1.4 µM.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Salvia / Diterpenos / Antineoplásicos / Antineoplásicos Fitogénicos Límite: Humans Idioma: En Revista: Phytochemistry Año: 2022 Tipo del documento: Article País de afiliación: Irán Pais de publicación: Reino Unido
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Salvia / Diterpenos / Antineoplásicos / Antineoplásicos Fitogénicos Límite: Humans Idioma: En Revista: Phytochemistry Año: 2022 Tipo del documento: Article País de afiliación: Irán Pais de publicación: Reino Unido