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Brain Amyloid Index as a Probable Marker Bridging Between Subjective Memory Complaint and Objective Cognitive Performance.
Choe, Young Min; Suh, Guk-Hee; Lee, Boung Chul; Choi, Ihn-Geun; Lee, Jun Ho; Kim, Hyun Soo; Hwang, Jaeuk; Kim, Jee Wook.
Afiliación
  • Choe YM; Department of Neuropsychiatry, Hallym University Dongtan Sacred Heart Hospital, Hwaseong, South Korea.
  • Suh GH; Department of Psychiatry, Hallym University College of Medicine, Chuncheon, South Korea.
  • Lee BC; Department of Neuropsychiatry, Hallym University Dongtan Sacred Heart Hospital, Hwaseong, South Korea.
  • Choi IG; Department of Psychiatry, Hallym University College of Medicine, Chuncheon, South Korea.
  • Lee JH; Department of Psychiatry, Hallym University College of Medicine, Chuncheon, South Korea.
  • Kim HS; Department of Neuropsychiatry, Hallym University Hangang Sacred Heart Hospital, Seoul, South Korea.
  • Hwang J; Department of Psychiatry, Hallym University College of Medicine, Chuncheon, South Korea.
  • Kim JW; Department of Psychiatry, Seoul W Psychiatric Office, Seoul, South Korea.
Front Neurosci ; 16: 912891, 2022.
Article en En | MEDLINE | ID: mdl-35860302
Background: The association between types of subjective memory complaint (SMC), poor objective cognitive performance, and brain Aß deposition have been poorly understood. We investigated the association between types of SMC and objective global cognitive performance, then assessed whether this association is mediated by the brain amyloid prediction index (API). Methods: In total, 173 non-demented older adults [63 cognitively normal (CN) and 110 mild cognitive impairment (MCI)] underwent comprehensive clinical assessments. Objective global cognitive performance and brain amyloid index were measured using the total score (TS) of the Consortium to Establish a Registry for Alzheimer's Disease neuropsychological battery and API, respectively. In total, four items of SMC from the subjective memory complaints questionnaire (SMCQ) (SMCQ1: a feeling of memory problem; SMCQ2: the feeling of worse memory than 10 years ago; SMCQ3: the feeling of worse memory than others of similar age; or SMCQ4: the feeling of difficulty in everyday life) in global memory function were assessed. Results: In non-demented and participants with MCI, SMCQ3-positive and SMCQ4-positive groups were associated with decreased TS. In participants with MCI, the SMCQ3-positive group was associated with increased API, and API was associated with decreased TS, but the SMCQ4-positive group did not. In addition, the association between the SMCQ3-positive group and poor TS disappeared when API was controlled as a covariate, indicating that API has a mediation effect. Conclusion: The present findings suggest that SMC, a feeling of worse memory performance than others in a similar age group, in the older adults without dementia is associated with poor objective cognitive performance via increased brain amyloid index.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Prognostic_studies Idioma: En Revista: Front Neurosci Año: 2022 Tipo del documento: Article País de afiliación: Corea del Sur Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Prognostic_studies Idioma: En Revista: Front Neurosci Año: 2022 Tipo del documento: Article País de afiliación: Corea del Sur Pais de publicación: Suiza