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The reversing effect of ondansetron on bupivacaine-induced sciatic nerve block.
Saltali, A O; Apiliogullari, S; Bagci, S; Sargon, M F; Celik, J B; Onal, O.
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  • Saltali AO; Department of Anesthesiology and Intensive Car, Selcuk University Medical Faculty, Konya, Turkey.
  • Apiliogullari S; Department of Anesthesiology and Intensive Car, Selcuk University Medical Faculty, Konya, Turkey.
  • Bagci S; Department of Pharmacology, Selcuk University Medical Faculty, Konya, Turkey.
  • Sargon MF; Department of Anatomy, Lokman Hekim University Medical Faculty, Ankara, Turkey.
  • Celik JB; Department of Anesthesiology and Intensive Car, Selcuk University Medical Faculty, Konya, Turkey.
  • Onal O; Department of Anesthesiology and Intensive Care, Selcuk University Medical Faculty, Konya, Turkey; 4Cleveland Clinic Anesthesiology Institute Outcomes Research Consortium, Cleveland, Ohio, United States of America.
Niger J Clin Pract ; 25(7): 1149-1157, 2022 Jul.
Article en En | MEDLINE | ID: mdl-35859477
Background and Aims: This experimental study was designed to test the hypothesis that ondansetron, a selective 5-HT3 receptor antagonist, would decrease the duration of motor, sensory, and proprioception blockade in a dose-dependent fashion in a bupivacaine-induced sciatic nerve blockade. Materials and Methods: Forty-nine male Wistar Albino rats who underwent unilateral sciatic nerve block were divided into seven groups with an equal number in each group. Group B: only perineural block (PB), Group BO200: PB and perineural 200 µg ondansetron, Group BO400: PB and perineural 400 µg ondansetron, Group BO800: PB and perineural 800 µg ondansetron, Group BO800IP: PB and intraperitoneal 800 µg ondansetron, Group O800: only perineural 800 µg ondansetron, Group S: sham-operated. The rats' motor, sensory, and proprioception functions were evaluated by a blinded investigator every 10 min until they returned to normal function. The recovery times of the motor, sensory, and proprioception functions were recorded and compared. All sciatic nerves were removed and examined by electron microscopy for neurotoxic signs. Results: In which sciatic nerve block was formed with bupivacaine, the duration of the motor, sensory, and proprioception functions blockade was decreased, and the duration to return to normal functions was significantly shortened at Group BO800 (p < 0.05). According to electron microscopy results, perineural 200 µg, 400 µg, and 800 µg ondansetron were not neurotoxic. Conclusion: This is the first study showing that perineural ondansetron administration (800 µg dose) reverses the effect of the local anesthetics and shortens the duration of the motor, sensory, and proprioception functions blockade.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Bupivacaína / Bloqueo Nervioso Límite: Animals Idioma: En Revista: Niger J Clin Pract Asunto de la revista: MEDICINA Año: 2022 Tipo del documento: Article País de afiliación: Turquía Pais de publicación: India
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Bupivacaína / Bloqueo Nervioso Límite: Animals Idioma: En Revista: Niger J Clin Pract Asunto de la revista: MEDICINA Año: 2022 Tipo del documento: Article País de afiliación: Turquía Pais de publicación: India