Hirschsprung's disease: a comparison of the nervous control of ganglionic and aganglionic smooth muscle in vitro.
J Pediatr Surg
; 22(5): 431-5, 1987 May.
Article
en En
| MEDLINE
| ID: mdl-3585666
Specimens from aganglionic (constricted) and ganglionic (dilated) gut were obtained from nine patients with Hirschsprung's disease. Transmural nerve stimulation of ganglionic smooth muscle in vitro evoked an initial relaxation followed by a contraction. This contraction was reduced but not abolished by atropine and it was further reduced by substance P antagonists. Guanethidine did not affect the electrically evoked responses. In aganglionic smooth muscle, an atropine-sensitive contraction but no initial relaxation was registered. Tetrodotoxin abolished all responses to electrical stimulation in both ganglionic and aganglionic specimens. Application of carbachol or substance P produced contraction and the adrenergic agonist isoprenaline or vasoactive intestinal peptide produced relaxation in ganglionic as well as aganglionic specimens. Two other gut neuropeptides, neuropeptide Y and galanin, were without effect. The results do not indicate a different receptor set up in ganglionic v aganglionic gut. The results are compatible with a lack of noncholinergic nonadrenergic inhibitory neurons in the aganglionic gut.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Ganglios
/
Enfermedad de Hirschsprung
/
Músculo Liso
Límite:
Child
/
Child, preschool
/
Female
/
Humans
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Infant
/
Male
Idioma:
En
Revista:
J Pediatr Surg
Año:
1987
Tipo del documento:
Article
Pais de publicación:
Estados Unidos