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Role of advanced glycation end products in the longitudinal association between muscular strength and psychotic symptoms among adolescents.
Suzuki, Kazuhiro; Yamasaki, Syudo; Miyashita, Mitsuhiro; Ando, Shuntaro; Toriumi, Kazuya; Yoshikawa, Akane; Nakanishi, Miharu; Morimoto, Yuko; Kanata, Sho; Fujikawa, Shinya; Endo, Kaori; Koike, Shinsuke; Usami, Satoshi; Itokawa, Masanari; Washizuka, Shinsuke; Hiraiwa-Hasegawa, Mariko; Meltzer, Herbert Y; Kasai, Kiyoto; Nishida, Atsushi; Arai, Makoto.
Afiliación
  • Suzuki K; Schizophrenia Research Project, Department of Psychiatry and Behavioral Sciences, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan.
  • Yamasaki S; Department of Psychiatry, Shinshu University School of Medicine, Matsumoto, Japan.
  • Miyashita M; Department of Psychiatry, Tokyo Metropolitan Matsuzawa Hospital, Tokyo, Japan.
  • Ando S; Department of Community Mental Health, Shinshu University School of Medicine, Matsumoto, Japan.
  • Toriumi K; Research Center for Social Science & Medicine, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan.
  • Yoshikawa A; Schizophrenia Research Project, Department of Psychiatry and Behavioral Sciences, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan.
  • Nakanishi M; Department of Psychiatry, Tokyo Metropolitan Matsuzawa Hospital, Tokyo, Japan.
  • Morimoto Y; Department of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
  • Kanata S; Schizophrenia Research Project, Department of Psychiatry and Behavioral Sciences, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan.
  • Fujikawa S; Schizophrenia Research Project, Department of Psychiatry and Behavioral Sciences, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan.
  • Endo K; Department of Psychiatry, Tokyo Metropolitan Matsuzawa Hospital, Tokyo, Japan.
  • Koike S; Research Center for Social Science & Medicine, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan.
  • Usami S; Research Center for Social Science & Medicine, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan.
  • Itokawa M; Department of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
  • Washizuka S; Department of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
  • Hiraiwa-Hasegawa M; Research Center for Social Science & Medicine, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan.
  • Meltzer HY; University of Tokyo Institute for Diversity and Adaptation of Human Mind (UTIDAHM), University of Tokyo, Tokyo, Japan.
  • Kasai K; Center for Research and Development on Transition from Secondary to Higher Education, The University of Tokyo, Tokyo, Japan.
  • Nishida A; Schizophrenia Research Project, Department of Psychiatry and Behavioral Sciences, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan.
  • Arai M; Department of Psychiatry, Tokyo Metropolitan Matsuzawa Hospital, Tokyo, Japan.
Schizophrenia (Heidelb) ; 8(1): 44, 2022 Apr 27.
Article en En | MEDLINE | ID: mdl-35853893
Muscular strength, assessed by handgrip, is a risk indicator for psychiatric disorders, including psychosis. However, the biological mechanisms underlying this association remain unclear. Since advanced glycation end products (AGEs) play a key role in skeletal muscle underdevelopment and psychosis, we examined the role of AGEs in the longitudinal association between muscular strength and psychotic symptoms among adolescents. We first evaluated the direction of the relationship between handgrip strength and urine levels of pentosidine, a representative AGEs in a population-based birth cohort of 1,542 adolescents at ages 12 and 14. Then, we examined the role of AGEs in the longitudinal association between handgrip strength and thought problems (TP), as a psychotic symptom indicator, in a subsample of 256 adolescents at ages 13 and 14. An autoregressive cross-lagged model revealed that handgrip strength at age 12 negatively predicted pentosidine levels at age 14 (ß = -0.20, p < 0.001), whereas pentosidine levels at age 12 did not predict handgrip strength at age 14 (ß = 0.04, p = 0.062). Moreover, pentosidine levels had a significant indirect effect on the relationship between handgrip strength and TP (standard indirect effect = -0.051, p = 0.012), which remained significant after adjusting for gender and preceded TP and pentosidine levels. Thus, adolescents with low muscular strength are at a high risk of developing psychotic symptoms, which could be mediated by AGEs. Future studies need to investigate whether interventions focused on muscular strength prevent the accumulation of AGEs and thereby prevent the development of psychosis.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Diagnostic_studies / Prognostic_studies / Risk_factors_studies Idioma: En Revista: Schizophrenia (Heidelb) Año: 2022 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Alemania
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Diagnostic_studies / Prognostic_studies / Risk_factors_studies Idioma: En Revista: Schizophrenia (Heidelb) Año: 2022 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Alemania