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Childhood maltreatment is associated with cortical thinning in people with eating disorders.
Cascino, Giammarco; Canna, Antonietta; Russo, Andrea Gerardo; Monaco, Francesco; Esposito, Fabrizio; Di Salle, Francesco; Monteleone, Palmiero; Monteleone, Alessio Maria.
Afiliación
  • Cascino G; Department of Medicine, Surgery and Dentistry 'Scuola Medica Salernitana', Section of Neurosciences, University of Salerno, Via Allende 1, Baronissi, 84081, Salerno, Italy. gcascino@unisa.it.
  • Canna A; Department of Advanced Medical and Surgical Sciences, University of Campania "Luigi Vanvitelli", Naples, Italy.
  • Russo AG; Department of Medicine, Surgery and Dentistry 'Scuola Medica Salernitana', Section of Neurosciences, University of Salerno, Via Allende 1, Baronissi, 84081, Salerno, Italy.
  • Monaco F; Department of Mental Health, ASL Salerno, Salerno, Italy.
  • Esposito F; Department of Advanced Medical and Surgical Sciences, University of Campania "Luigi Vanvitelli", Naples, Italy.
  • Di Salle F; Department of Medicine, Surgery and Dentistry 'Scuola Medica Salernitana', Section of Neurosciences, University of Salerno, Via Allende 1, Baronissi, 84081, Salerno, Italy.
  • Monteleone P; Department of Medicine, Surgery and Dentistry 'Scuola Medica Salernitana', Section of Neurosciences, University of Salerno, Via Allende 1, Baronissi, 84081, Salerno, Italy.
  • Monteleone AM; Department of Psychiatry, University of Campania "Luigi Vanvitelli", Naples, Italy.
Eur Arch Psychiatry Clin Neurosci ; 273(2): 459-466, 2023 Mar.
Article en En | MEDLINE | ID: mdl-35852616
Childhood maltreatment (CM) is a non-specific risk factor for eating disorders (ED) and is associated with a greater severity in their clinical presentation and poorer treatment outcome. These data suggest that maltreated people with ED may be biologically other than clinically different from non-maltreated people. The aim of the present study was to investigate cortical thickness (CT), a possible biomarker of neurodevelopment, in people with ED with or without history of CM and in healthy women. Twenty-four healthy women, 26 with anorexia nervosa and 24 with bulimia nervosa underwent a 3T MRI scan. All participants filled in the childhood trauma questionnaire. All neuroimaging data were processed by FreeSurfer. Twenty-four participants with ED were identified as maltreated and 26 participants with ED as non-maltreated. All healthy women were non-maltreated. Compared to healthy women, maltreated people with ED showed lower CT in the left rostral anterior cingulate gyrus, while compared to people with ED without history of CM showed lower CT values in the left superior frontal and in right caudal middle frontal and superior parietal gyri. No significant differences emerged in CT measures between healthy women and people with ED without history of CM. The present findings show for the first time that in adult people with ED childhood maltreatment is associated with cortical thinning in areas implicated in the modulation of brain processes that are acknowledged to play a role in the psychopathology of ED.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trastornos de Alimentación y de la Ingestión de Alimentos / Maltrato a los Niños / Bulimia Nerviosa Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Adult / Child / Female / Humans Idioma: En Revista: Eur Arch Psychiatry Clin Neurosci Asunto de la revista: NEUROLOGIA / PSIQUIATRIA Año: 2023 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Alemania
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trastornos de Alimentación y de la Ingestión de Alimentos / Maltrato a los Niños / Bulimia Nerviosa Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Adult / Child / Female / Humans Idioma: En Revista: Eur Arch Psychiatry Clin Neurosci Asunto de la revista: NEUROLOGIA / PSIQUIATRIA Año: 2023 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Alemania