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Individual participant data meta-analysis of trials comparing frozen versus fresh embryo transfer strategy (INFORM): a protocol.
Wang, Rui; McLernon, David J; Lai, Shimona; Showell, Marian G; Chen, Zi-Jiang; Wei, Daimin; Legro, Richard S; Wang, Ze; Sun, Yun; Wu, Keliang; Vuong, Lan N; Hardy, Pollyanna; Pinborg, Anja; Stormlund, Sacha; Santamaría, Xavier; Simón, Carlos; Blockeel, Christophe; Mol, Femke; Ferraretti, Anna P; Shapiro, Bruce S; Garner, Forest C; Li, Rong; Venetis, Christos A; Mol, Ben W; Bhattacharya, Siladitya; Maheshwari, Abha.
Afiliación
  • Wang R; Department of Obstetrics and Gynaecology, Monash University, Clayton, VIC, Australia r.wang@monash.edu.
  • McLernon DJ; Institute of Applied Health Sciences, University of Aberdeen, Aberdeen, UK.
  • Lai S; Department of Obstetrics and Gynaecology, Monash University, Clayton, VIC, Australia.
  • Showell MG; Obstetrics and Gynaecology, University of Aukland, Auckland, New Zealand.
  • Chen ZJ; Centre for Reproductive Medicine, Shandong University, Jinan, Shandong, China.
  • Wei D; Centre for Reproductive Medicine, Shandong University, Jinan, Shandong, China.
  • Legro RS; Department of Obstetrics and Gynecology and Public Health Sciences, Penn State College of Medicine, Hershey, PA, USA.
  • Wang Z; Centre for Reproductive Medicine, Shandong University, Jinan, Shandong, China.
  • Sun Y; Shanghai Key laboratory for Assisted Reproduction and Reproductive Genetics, Center for Reproductive Medicine, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
  • Wu K; Centre for Reproductive Medicine, Shandong University, Jinan, Shandong, China.
  • Vuong LN; Department of Obstetrics and Gynaecology, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, Vietnam.
  • Hardy P; National Perinatal Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK.
  • Pinborg A; Fertility Clinic, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.
  • Stormlund S; Fertility Clinic, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.
  • Santamaría X; Igenomix Foundation, INCLIVA Health Research Institute, Valencia, Spain.
  • Simón C; Igenomix Foundation, INCLIVA Health Research Institute, Valencia, Spain.
  • Blockeel C; Centre for Reproductive Medicine, Universitair Ziekenhuis Brussel, Brussels, Belgium.
  • Mol F; Centre for Reproductive Medicine, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
  • Ferraretti AP; Reproductive Medicine Unit, SISMeR, Bologna, Emilia-Romagna, Italy.
  • Shapiro BS; Department of Obstetrics and Gynecology, Kirk Kerkorian School of Medicine, Las Vegas, NV, USA.
  • Garner FC; Fertility Center of Las Vegas, Las Vegas, NV, USA.
  • Li R; Department of Obstetrics and Gynecology, Kirk Kerkorian School of Medicine, Las Vegas, NV, USA.
  • Venetis CA; Fertility Center of Las Vegas, Las Vegas, NV, USA.
  • Mol BW; Centre for Reproductive Medicine, Peking University Third Hospital, Beijing, China.
  • Bhattacharya S; Centre for Big Data Research in Health & School of Women's and Children's Health, University of New South Wales, Sydney, NSW, Australia.
  • Maheshwari A; Department of Obstetrics and Gynaecology, Monash University, Clayton, VIC, Australia.
BMJ Open ; 12(7): e062578, 2022 07 18.
Article en En | MEDLINE | ID: mdl-35851030
INTRODUCTION: Existing randomised controlled trials (RCTs) comparing a freeze-all embryo transfer strategy and a fresh embryo transfer strategy have shown conflicting results. A freeze-all or a fresh transfer policy may be preferable for some couples undergoing in-vitro fertilisation (IVF), but it is unclear which couples would benefit most from each policy, how and under which protocols. Therefore, we plan a systematic review and individual participant data meta-analysis of RCTs comparing a freeze-all and a fresh transfer policy. METHODS AND ANALYSIS: We will search electronic databases (Medline, Embase, PsycINFO and CENTRAL) and trial registries (ClinicalTrials.gov and the International Clinical Trials Registry Platform) from their inception to present to identify eligible RCTs. We will also check reference lists of relevant papers. The search was performed on 23 September 2020 and will be updated. We will include RCTs comparing a freeze-all embryo transfer strategy and a fresh embryo transfer strategy in couples undergoing IVF. The primary outcome will be live birth resulting from the first embryo transfer. All outcomes listed in the core outcome set for infertility research will be reported. We will invite the lead investigators of eligible trials to join the Individual participant data meta-analysis of trials comparing frozen versus fresh embryo transfer strategy (INFORM) collaboration and share the deidentified individual participant data (IPD) of their trials. We will harmonise the IPD and perform a two-stage meta-analysis and examine treatment-covariate interactions for important baseline characteristics. ETHICS AND DISSEMINATION: The study ethics have been granted by the Monash University Human Research Ethics Committee (Project ID: 30391). The findings will be disseminated via presentations at international conferences and publication in peer-reviewed journals. PROSPERO REGISTRATION NUMBER: CRD42021296566.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Transferencia de Embrión / Nacimiento Vivo Tipo de estudio: Clinical_trials / Guideline / Prognostic_studies / Systematic_reviews Aspecto: Ethics Límite: Female / Humans / Pregnancy Idioma: En Revista: BMJ Open Año: 2022 Tipo del documento: Article País de afiliación: Australia Pais de publicación: Reino Unido
Texto completo
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XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Transferencia de Embrión / Nacimiento Vivo Tipo de estudio: Clinical_trials / Guideline / Prognostic_studies / Systematic_reviews Aspecto: Ethics Límite: Female / Humans / Pregnancy Idioma: En Revista: BMJ Open Año: 2022 Tipo del documento: Article País de afiliación: Australia Pais de publicación: Reino Unido