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Novel donepezil-chalcone-rivastigmine hybrids as potential multifunctional anti-Alzheimer's agents: Design, synthesis, in vitro biological evaluation, in vivo and in silico studies.
Sang, Zhipei; Bai, Ping; Ban, Yujuan; Wang, Keren; Wu, Anguo; Mi, Jing; Hu, Jiaqi; Xu, Rui; Zhu, Gaofeng; Wang, Jianta; Zhang, Jiquan; Wang, Changning; Tan, Zhenghuai; Tang, Lei.
Afiliación
  • Sang Z; State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Provincial Engineering Technology Research Center for Chemical Drug R&D, Guizhou Medical University, Guiyang 550004, China; College of Chemistry and Pharmaceutical Engineering, Nanyang Normal University, Nanyang 4730
  • Bai P; Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA.
  • Ban Y; State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Provincial Engineering Technology Research Center for Chemical Drug R&D, Guizhou Medical University, Guiyang 550004, China.
  • Wang K; College of Chemistry and Pharmaceutical Engineering, Nanyang Normal University, Nanyang 473061, China.
  • Wu A; Sichuan Key Medical Laboratory of New Drug Discovery and Drugability Evaluation, Southwest Medical University, Luzhou 646000, China.
  • Mi J; College of Chemistry and Pharmaceutical Engineering, Nanyang Normal University, Nanyang 473061, China.
  • Hu J; State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Provincial Engineering Technology Research Center for Chemical Drug R&D, Guizhou Medical University, Guiyang 550004, China.
  • Xu R; State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Provincial Engineering Technology Research Center for Chemical Drug R&D, Guizhou Medical University, Guiyang 550004, China.
  • Zhu G; State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Provincial Engineering Technology Research Center for Chemical Drug R&D, Guizhou Medical University, Guiyang 550004, China.
  • Wang J; State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Provincial Engineering Technology Research Center for Chemical Drug R&D, Guizhou Medical University, Guiyang 550004, China.
  • Zhang J; State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Provincial Engineering Technology Research Center for Chemical Drug R&D, Guizhou Medical University, Guiyang 550004, China.
  • Wang C; Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA. Electronic address: cwang15@mgh.harvard.edu.
  • Tan Z; Institute of Traditional Chinese Medicine Pharmacology and Toxicology, Sichuan Academy of Chinese Medicine Sciences, Chengdu 610041, China. Electronic address: tanzhh616@163.com.
  • Tang L; State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Provincial Engineering Technology Research Center for Chemical Drug R&D, Guizhou Medical University, Guiyang 550004, China. Electronic address: tl1974@163.com.
Bioorg Chem ; 127: 106007, 2022 10.
Article en En | MEDLINE | ID: mdl-35849893
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Chalcona / Fármacos Neuroprotectores / Chalconas / Enfermedad de Alzheimer Límite: Animals Idioma: En Revista: Bioorg Chem Año: 2022 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Chalcona / Fármacos Neuroprotectores / Chalconas / Enfermedad de Alzheimer Límite: Animals Idioma: En Revista: Bioorg Chem Año: 2022 Tipo del documento: Article Pais de publicación: Estados Unidos