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Effect of chronic lithium on mechanical sensitivity and trabecular bone loss induced by type-1 diabetes mellitus in mice.
Graniel-Amador, Mayra Alejandra; Torres-Rodríguez, Héctor Fabian; Martínez-Mendoza, Ruth Elena; Vargas-Muñoz, Virginia Margarita; Acosta-González, Rosa Issel; Castañeda-Corral, Gabriela; Muñoz-Islas, Enriqueta; Jiménez-Andrade, Juan Miguel.
Afiliación
  • Graniel-Amador MA; Laboratorio de Farmacología, Unidad Académica Multidisciplinaria Reynosa-Aztlán, UAT, Reynosa, Tamaulipas, México.
  • Torres-Rodríguez HF; Laboratorio de Farmacología, Unidad Académica Multidisciplinaria Reynosa-Aztlán, UAT, Reynosa, Tamaulipas, México.
  • Martínez-Mendoza RE; Laboratorio de Farmacología, Unidad Académica Multidisciplinaria Reynosa-Aztlán, UAT, Reynosa, Tamaulipas, México.
  • Vargas-Muñoz VM; Laboratorio de Farmacología, Unidad Académica Multidisciplinaria Reynosa-Aztlán, UAT, Reynosa, Tamaulipas, México.
  • Acosta-González RI; Laboratorio de Farmacología, Unidad Académica Multidisciplinaria Reynosa-Aztlán, UAT, Reynosa, Tamaulipas, México.
  • Castañeda-Corral G; Facultad de Medicina, Universidad Autónoma del Estado de Morelos, Cuernavaca, Morelos, México.
  • Muñoz-Islas E; Laboratorio de Farmacología, Unidad Académica Multidisciplinaria Reynosa-Aztlán, UAT, Reynosa, Tamaulipas, México.
  • Jiménez-Andrade JM; Laboratorio de Farmacología, Unidad Académica Multidisciplinaria Reynosa-Aztlán, UAT, Reynosa, Tamaulipas, México. jimenez.andrade1810@gmail.com.
Biometals ; 35(5): 1033-1042, 2022 10.
Article en En | MEDLINE | ID: mdl-35849260
Type-1 diabetes mellitus (T1DM) is a chronic condition characterized by long-term hyperglycemia that results in several complications such as painful peripheral neuropathy, bone deterioration, and increased risk of bone fractures. Lithium, a first-line therapy for bipolar disorder, has become an attractive agent for attenuating peripheral neuropathy and menopause-induced bone loss. Therefore, our aim was to determine the effect of chronic lithium treatment on mechanical hypersensitivity and trabecular bone loss induced by T1DM in mice. T1DM was induced in male C57BL/6J mice by intraperitoneal injection of streptozotocin (STZ, 50 mg/kg/day, for 5 consecutive days). 12 weeks after T1DM-induction, mice received a daily intraperitoneal injection of vehicle, 30 or 60 mg/kg lithium (as LiCl) for 6 weeks. Throughout the treatment period, blood glucose levels and mechanical sensitivity were evaluated every 2 weeks. After lithium treatment, the femur and L5 vertebra were harvested for microcomputed tomography (microCT) analysis. T1DM mice showed significant hyperglycemia, mechanical hypersensitivity, and significant trabecular bone loss as compared with the control group. Chronic lithium treatment did not revert the hindpaw mechanical hypersensitivity nor hyperglycemia associated to T1DM induced by STZ. In contrast, microCT analysis revealed that lithium reverted, in a dose-dependent manner, the loss of trabecular bone associated to T1DM induced by STZ at both the distal femur and L5 vertebra. Lithium treatment by itself did not affect any trabecular bone parameter in non-diabetic mice.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Diabetes Mellitus Experimental / Diabetes Mellitus Tipo 1 / Hiperglucemia Tipo de estudio: Diagnostic_studies Límite: Animals Idioma: En Revista: Biometals Asunto de la revista: BIOQUIMICA Año: 2022 Tipo del documento: Article Pais de publicación: Países Bajos
Texto completo
Añadir a Mi BVS
Imprimir
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Diabetes Mellitus Experimental / Diabetes Mellitus Tipo 1 / Hiperglucemia Tipo de estudio: Diagnostic_studies Límite: Animals Idioma: En Revista: Biometals Asunto de la revista: BIOQUIMICA Año: 2022 Tipo del documento: Article Pais de publicación: Países Bajos