Use of the systemic inflammation response index (SIRI) as a novel prognostic marker for patients on peritoneal dialysis.

Li, Jiaqi; Li, Yingxue; Zou, Yaowei; Chen, Yaode; He, Lizhen; Wang, Ying; Zhou, Jingxuan; Xiao, Fangqi; Niu, Hongxin; Lu, Lingli

Li, Jiaqi; Li, Yingxue; Zou, Yaowei; Chen, Yaode; He, Lizhen; Wang, Ying; Zhou, Jingxuan; Xiao, Fangqi; Niu, Hongxin; Lu, Lingli.

Afiliación

Li J; Division of Nephrology, Zhujiang Hospital, Southern Medical University, Guangzhou, PR China.
Li Y; Division of Nephrology, Zhujiang Hospital, Southern Medical University, Guangzhou, PR China.
Zou Y; Division of Nephrology, Zhujiang Hospital, Southern Medical University, Guangzhou, PR China.
Chen Y; Department of General Practice, Zhujiang Hospital, Southern Medical University, Guangzhou, PR China.
He L; Department of General Practice, Zhujiang Hospital, Southern Medical University, Guangzhou, PR China.
Wang Y; General Practice and Special Medical Service Center, Zhujiang Hospital, Southern Medical University, Guangzhou, PR China.
Zhou J; General Practice and Special Medical Service Center, Zhujiang Hospital, Southern Medical University, Guangzhou, PR China.
Xiao F; General Practice and Special Medical Service Center, Zhujiang Hospital, Southern Medical University, Guangzhou, PR China.
Niu H; General Practice and Special Medical Service Center, Zhujiang Hospital, Southern Medical University, Guangzhou, PR China.
Lu L; Department of General Practice, Zhujiang Hospital, Southern Medical University, Guangzhou, PR China.

Ren Fail ; 44(1): 1227-1235, 2022 Dec.

Article en En | MEDLINE | ID: mdl-35848372

RESUMEN

BACKGROUND: The systemic inflammatory response index (SIRI), a novel inflammation maker, has proven to be associated with prognostic outcomes in various diseases. However, few studies have been conducted assessing how SIRI may influence outcomes of patients on peritoneal dialysis (PD). Herein, we assessed the predictive value of SIRI on mortality all-cause mortality, including cardiovascular disease (CVD) in PD patients. METHODS: A total of 646 PD patients were enrolled in this study. PD patients received regular PD treatments at the Zhujiang Hospital from 1 January 2011 to 31 December 2018. SIRI values could be computed as follows: neutrophil count × monocyte count/lymphocyte count. Patients were divided into two groups according to the median level of SIRI. Cox regression analysis and Kaplan-Meier methods were applied to analyze the relationship between SIRI and mortality outcomes in PD patients. RESULTS: During the median 31-month follow-up period, 97 (15.0%) PD patients died from all-causes, and 47 (49.0%) died of CVD. Kaplan-Meier analyses revealed that a high SIRI corresponded to the high mortality of all-cause deaths, including CVD (both p < 0.001) in patients on PD. After adjusting for potential confounders, the higher SIRI level was significantly associated with an increased all-cause mortality (HR: 2.007, 95% CI: 1.304-3.088, p = 0.002) and cardiovascular mortality (HR: 2.847, 95% CI: 1.445-5.608, p = 0.002). CONCLUSIONS: SIRI was a promising predictor of mortality in PD patients, with a higher SIRI corresponding to increased risk of mortality.

Asunto(s)

Enfermedades Cardiovasculares; Diálisis Peritoneal; Enfermedades Cardiovasculares/etiología; Humanos; Inflamación; Pronóstico; Estudios Retrospectivos

Palabras clave

Systemic inflammatory response index; all-cause mortality; cardiovascular disease; microinflammation; peritoneal dialysis

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedades Cardiovasculares / Diálisis Peritoneal Tipo de estudio: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: Ren Fail Asunto de la revista: NEFROLOGIA Año: 2022 Tipo del documento: Article Pais de publicación: Reino Unido

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