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Leg-type form of idiopathic multicentric Castleman disease associated with severe lower extremity chronic venous/lymphatic disease.
Ballul, Thomas; Belfeki, Nabil; de Masson, Adèle; Meignin, Véronique; Woerther, Paul-Louis; Martin, Antoine; Poullot, Elsa; Wargnier, Alain; Fadlallah, Jehane; Garzaro, Margaux; Malphettes, Marion; Fieschi, Claire; Maisonobe, Lucas; Bensekhri, Hayat; Guillot, Hélène; Bertinchamp, Rémi; Jachiet, Marie; Poirot, Justine; Galicier, Lionel; Oksenhendler, Eric; Boutboul, David.
Afiliación
  • Ballul T; Clinical Immunology Department Hôpital Saint Louis, Université de Paris Paris France.
  • Belfeki N; Internal Medicine Department Centre hospitalier de Melun Melun France.
  • de Masson A; Dermatology Department Université de Paris Paris France.
  • Meignin V; Pathology Department Hôpital Saint Louis Université de Paris Paris France.
  • Woerther PL; Bacteriology and Virology Department Hôpital Henri Mondor Créteil France.
  • Martin A; Pathology Department Hôpital Avicenne Université Sorbonne Paris Nord Bobigny France.
  • Poullot E; Pathology Department Hôpital Henri Mondor Université Paris-Est Créteil Créteil France.
  • Wargnier A; Bacteriology Department Hôpital Saint Louis Université de Paris Paris France.
  • Fadlallah J; Clinical Immunology Department Hôpital Saint Louis, Université de Paris Paris France.
  • Garzaro M; National Reference Center for Castleman disease Hôpital Saint Louis Université de Paris Paris France.
  • Malphettes M; Clinical Immunology Department Hôpital Saint Louis, Université de Paris Paris France.
  • Fieschi C; National Reference Center for Castleman disease Hôpital Saint Louis Université de Paris Paris France.
  • Maisonobe L; Clinical Immunology Department Hôpital Saint Louis, Université de Paris Paris France.
  • Bensekhri H; National Reference Center for Castleman disease Hôpital Saint Louis Université de Paris Paris France.
  • Guillot H; Clinical Immunology Department Hôpital Saint Louis, Université de Paris Paris France.
  • Bertinchamp R; National Reference Center for Castleman disease Hôpital Saint Louis Université de Paris Paris France.
  • Jachiet M; Clinical Immunology Department Hôpital Saint Louis, Université de Paris Paris France.
  • Poirot J; Internal Medicine Department Groupe Hospitalier Nord Essonne Longjumeau France.
  • Galicier L; Internal Medicine Department Hôpital Robert Ballanger Université Sorbonne Paris Nord Aulnay-Sous-Bois France.
  • Oksenhendler E; Clinical Immunology Department Hôpital Saint Louis, Université de Paris Paris France.
  • Boutboul D; National Reference Center for Castleman disease Hôpital Saint Louis Université de Paris Paris France.
EJHaem ; 3(1): 175-179, 2022 Feb.
Article en En | MEDLINE | ID: mdl-35846183
Idiopathic multicentric Castleman disease (iMCD) is a lymphoproliferative disease of unknown etiology. Deciphering mechanisms involved in CD pathogenesis may help improving patients' care. Six cases of stereotyped sub-diaphragmatic iMCD affecting lower limb-draining areas and associated with severe and often ulcerative lower extremity chronic dermatological condition were identified in our cohort. Pathological examination revealed mixed or plasma-cell type MCD. In three patients, shotgun metagenomics failed to identify any pathogen in involved lymph nodes. Antibiotics had a suspensive effect while rituximab and tocilizumab failed to improve the condition. This novel entity requires a specific approach and exclusion of potentially harmful immunomodulation.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Risk_factors_studies Idioma: En Revista: EJHaem Año: 2022 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Risk_factors_studies Idioma: En Revista: EJHaem Año: 2022 Tipo del documento: Article Pais de publicación: Estados Unidos