Hyperammonaemia induces mitochondrial dysfunction and neuronal cell death.

Angelova, Plamena R; Kerbert, Annarein J C; Habtesion, Abeba; Hall, Andrew; Abramov, Andrey Y; Jalan, Rajiv

Angelova, Plamena R; Kerbert, Annarein J C; Habtesion, Abeba; Hall, Andrew; Abramov, Andrey Y; Jalan, Rajiv.

Afiliación

Angelova PR; Queen Square Institute of Neurology, University College London, London, UK.
Kerbert AJC; Institute for Liver and Digestive Health, University College London, Royal Free Campus, London, UK.
Habtesion A; Institute for Liver and Digestive Health, University College London, Royal Free Campus, London, UK.
Hall A; Sheila Sherlock Liver Centre, Royal Free London NHS Foundation Trust, London, UK.
Abramov AY; Queen Square Institute of Neurology, University College London, London, UK.
Jalan R; Institute for Liver and Digestive Health, University College London, Royal Free Campus, London, UK.

JHEP Rep ; 4(8): 100510, 2022 Aug.

Article en En | MEDLINE | ID: mdl-35845295

Palabras clave

Ammonia; BDL, bile duct ligation; CA1, cornu ammonis 1; CA3, cornu ammonis 3; CNS, central nervous system; Cell death; DG, dentate gyrus; DIV, days in vitro; ETC, electron transport chain; FCCP, carbonyl cyanide 4-(trifluoromethoxy) phenylhydrazone; GFAP, glial fibrillary acidic protein; HE, hepatic encephalopathy; HEt, dihydroethidium; Hepatic encephalopathy; LP, lipid peroxidation; Liver cirrhosis; Mitochondrial function; NaCN, sodium cyanide; OP, ornithine phenylacetate; PI, propidium iodide; ROI, region of interest; ROS, reactive oxygen species; TCA, tricarboxylic acid; TMRM, tetramethyl rhodamine, methyl ester; mPT, mitochondrial permeability transition; Δψm, mitochondrial membrane potential

Texto completo

Añadir a Mi BVS

Imprimir

XML

PubMed Links

Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Prognostic_studies Idioma: En Revista: JHEP Rep Año: 2022 Tipo del documento: Article País de afiliación: Reino Unido Pais de publicación: Países Bajos

Texto completo

Añadir a Mi BVS

Imprimir

XML

PubMed Links

Buscar en Google