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Maternal SMCHD1 controls both imprinted Xist expression and imprinted X chromosome inactivation.
Wanigasuriya, Iromi; Kinkel, Sarah A; Beck, Tamara; Roper, Ellise A; Breslin, Kelsey; Lee, Heather J; Keniry, Andrew; Ritchie, Matthew E; Blewitt, Marnie E; Gouil, Quentin.
Afiliación
  • Wanigasuriya I; Walter and Eliza Hall Institute of Medical Research, Parkville, Australia.
  • Kinkel SA; The Department of Medical Biology, The University of Melbourne, Parkville, Australia.
  • Beck T; Walter and Eliza Hall Institute of Medical Research, Parkville, Australia.
  • Roper EA; The Department of Medical Biology, The University of Melbourne, Parkville, Australia.
  • Breslin K; Walter and Eliza Hall Institute of Medical Research, Parkville, Australia.
  • Lee HJ; The Department of Medical Biology, The University of Melbourne, Parkville, Australia.
  • Keniry A; The School of Biomedical Sciences and Pharmacy, The University of Newcastle, Newcastle, Australia.
  • Ritchie ME; Walter and Eliza Hall Institute of Medical Research, Parkville, Australia.
  • Blewitt ME; The Department of Medical Biology, The University of Melbourne, Parkville, Australia.
  • Gouil Q; The School of Biomedical Sciences and Pharmacy, The University of Newcastle, Newcastle, Australia.
Epigenetics Chromatin ; 15(1): 26, 2022 07 18.
Article en En | MEDLINE | ID: mdl-35843975
Embryonic development is dependent on the maternal supply of proteins through the oocyte, including factors setting up the adequate epigenetic patterning of the zygotic genome. We previously reported that one such factor is the epigenetic repressor SMCHD1, whose maternal supply controls autosomal imprinted expression in mouse preimplantation embryos and mid-gestation placenta. In mouse preimplantation embryos, X chromosome inactivation is also an imprinted process. Combining genomics and imaging, we show that maternal SMCHD1 is required not only for the imprinted expression of Xist in preimplantation embryos, but also for the efficient silencing of the inactive X in both the preimplantation embryo and mid-gestation placenta. These results expand the role of SMCHD1 in enforcing the silencing of Polycomb targets. The inability of zygotic SMCHD1 to fully restore imprinted X inactivation further points to maternal SMCHD1's role in setting up the appropriate chromatin environment during preimplantation development, a critical window of epigenetic remodelling.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteínas Cromosómicas no Histona / Inactivación del Cromosoma X / ARN Largo no Codificante Límite: Animals Idioma: En Revista: Epigenetics Chromatin Año: 2022 Tipo del documento: Article País de afiliación: Australia Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteínas Cromosómicas no Histona / Inactivación del Cromosoma X / ARN Largo no Codificante Límite: Animals Idioma: En Revista: Epigenetics Chromatin Año: 2022 Tipo del documento: Article País de afiliación: Australia Pais de publicación: Reino Unido