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Can Mycobacterium tuberculosis infection lead to cancer? Call for a paradigm shift in understanding TB and cancer.
Malik, Asrar A; Sheikh, Javaid A; Ehtesham, Nasreen Z; Hira, Subhash; Hasnain, Seyed E.
Afiliación
  • Malik AA; Department of Life Science, School of Basic Sciences and Research, Sharda University, Greater Noida, India.
  • Sheikh JA; Department of Biotechnology, Jamia Hamdard, New Delhi, India.
  • Ehtesham NZ; ICMR-National Institute of Pathology, Safdarjung Hospital Campus, New Delhi, India.
  • Hira S; Department of Global Health, University of Washington, Seattle, WA, USA. Electronic address: hiras2@uw.edu.
  • Hasnain SE; Department of Life Science, School of Basic Sciences and Research, Sharda University, Greater Noida, India; Department of Biochemical Engineering and Biotechnology, Indian Institute of Technology-Delhi, New Delhi, India. Electronic address: seyedhasnain@gmail.com.
Int J Med Microbiol ; 312(5): 151558, 2022 Jul.
Article en En | MEDLINE | ID: mdl-35842995
Infections are known to cause tumours though more attributed to viruses. Strong epidemiological links suggest association between bacterial infections and cancers as exemplified by Helicobacter pylori and Salmonella spp. Infection with Mycobacterium tuberculosis (M. tb), the etiological agent of tuberculosis (TB), has been reported to predispose patients to lung cancers and possibly in other organs as well. While this etiopathogenesis warrant inclusion of M. tb in IARC's (International Agency for Research on Cancer) classified carcinogenic agents, the lack of well-defined literature and direct experimental studies have barred the research community from accepting the role of M. tb as a carcinogen. The background research, case studies, and experimental data extensively reviewed in Roy et al., 2021; provoke the debate for elucidating carcinogenic properties of M. tb. Moreover, proper, timely and correct diagnosis of both diseases (which often mimic each other) will save millions of lives that are misdiagnosed. In addition, use of Anti Tubercular therapy (ATT) in misdiagnosed non-TB patients contributes to drug resistance in population thereby severely impacting TB disease control measures. Research in this arena can further aid in saving billions of dollars by preventing the superfluous use of cancer drugs. In order to achieve these goals, it is imperative to identify the underlying mechanism of M. tb infection acting as major risk factor for cancer.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Tuberculosis / Helicobacter pylori / Mycobacterium tuberculosis / Neoplasias Tipo de estudio: Diagnostic_studies / Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: Int J Med Microbiol Asunto de la revista: MICROBIOLOGIA Año: 2022 Tipo del documento: Article País de afiliación: India Pais de publicación: Alemania
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Tuberculosis / Helicobacter pylori / Mycobacterium tuberculosis / Neoplasias Tipo de estudio: Diagnostic_studies / Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: Int J Med Microbiol Asunto de la revista: MICROBIOLOGIA Año: 2022 Tipo del documento: Article País de afiliación: India Pais de publicación: Alemania