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Engineered models for placental toxicology: Emerging approaches based on tissue decellularization.
Parameshwar, Prabu Karthick; Sagrillo-Fagundes, Lucas; Azevedo Portilho, Nathalia; Pastor, William A; Vaillancourt, Cathy; Moraes, Christopher.
Afiliación
  • Parameshwar PK; Department of Biological and Biomedical Engineering, McGill University, Montréal, Québec, Canada.
  • Sagrillo-Fagundes L; Department of Chemical Engineering, McGill University, Montréal, Québec, Canada.
  • Azevedo Portilho N; Department of Chemical Engineering, McGill University, Montréal, Québec, Canada; Department of Biochemistry, McGill University, Montréal, Québec, Canada.
  • Pastor WA; Department of Biochemistry, McGill University, Montréal, Québec, Canada; Rosalind & Morris Goodman Cancer Institute, McGill University, Montréal, Québec, Canada.
  • Vaillancourt C; INRS-Centre Armand-Frappier Santé Biotechnologie, Laval, Québec, Canada; Department of Obstetrics and Gynecology, Université de Montréal, Montréal, Québec, Canada.
  • Moraes C; Department of Biological and Biomedical Engineering, McGill University, Montréal, Québec, Canada; Department of Chemical Engineering, McGill University, Montréal, Québec, Canada; Rosalind & Morris Goodman Cancer Institute, McGill University, Montréal, Québec, Canada; Division of Experimental Med
Reprod Toxicol ; 112: 148-159, 2022 09.
Article en En | MEDLINE | ID: mdl-35840119
Recent increases in prescriptions and illegal drug use as well as exposure to environmental contaminants during pregnancy have highlighted the critical importance of placental toxicology in understanding and identifying risks to both mother and fetus. Although advantageous for basic science, current in vitro models often fail to capture the complexity of placental response, likely due to their inability to recreate and monitor aspects of the microenvironment including physical properties, mechanical forces and stiffness, protein composition, cell-cell interactions, soluble and physicochemical factors, and other exogenous cues. Tissue engineering holds great promise in addressing these challenges and provides an avenue to better understand basic biology, effects of toxic compounds and potential therapeutics. The key to success lies in effectively recreating the microenvironment. One strategy to do this would be to recreate individual components and then combine them. However, this becomes challenging due to variables present according to conditions such as tissue location, age, health status and lifestyle. The extracellular matrix (ECM) is known to influence cellular fate by working as a storage of factors. Decellularized ECM (dECM) is a recent tool that allows usage of the original ECM in a refurbished form, providing a relatively reliable representation of the microenvironment. This review focuses on using dECM in modified forms such as whole organs, scaffold sheets, electrospun nanofibers, hydrogels, 3D printing, and combinations as building blocks to recreate aspects of the microenvironment to address general tissue engineering and toxicology challenges, thus illustrating their potential as tools for future placental toxicology studies.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Placenta / Matriz Extracelular Tipo de estudio: Prognostic_studies Aspecto: Patient_preference Límite: Female / Humans / Pregnancy Idioma: En Revista: Reprod Toxicol Asunto de la revista: EMBRIOLOGIA / MEDICINA REPRODUTIVA / TOXICOLOGIA Año: 2022 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Placenta / Matriz Extracelular Tipo de estudio: Prognostic_studies Aspecto: Patient_preference Límite: Female / Humans / Pregnancy Idioma: En Revista: Reprod Toxicol Asunto de la revista: EMBRIOLOGIA / MEDICINA REPRODUTIVA / TOXICOLOGIA Año: 2022 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Estados Unidos