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Polymer-coated BiOCl nanosheets for safe and regioselective gastrointestinal X-ray imaging.
Zelepukin, I V; Ivanov, I N; Mirkasymov, A B; Shevchenko, K G; Popov, A A; Prasad, P N; Kabashin, A V; Deyev, S M.
Afiliación
  • Zelepukin IV; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences, Moscow, Russia; National Research Nuclear University "MEPhI", Moscow, Russia. Electronic address: zelepukin@phystech.edu.
  • Ivanov IN; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences, Moscow, Russia; National Research Nuclear University "MEPhI", Moscow, Russia; Pirogov Russian National Research Medical University (RNRMU), Moscow, Russia.
  • Mirkasymov AB; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences, Moscow, Russia.
  • Shevchenko KG; Institute of Сytology of the Russian Academy of Sciences, Saint Petersburg, Russia.
  • Popov AA; National Research Nuclear University "MEPhI", Moscow, Russia.
  • Prasad PN; National Research Nuclear University "MEPhI", Moscow, Russia; Institute for Lasers, Photonics and Biophotonics, University at Buffalo, Buffalo, United States.
  • Kabashin AV; Aix Marseille University, CNRS, LP3, Campus de Luminy - case 917, 13288 Marseille Cedex, France.
  • Deyev SM; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences, Moscow, Russia; National Research Nuclear University "MEPhI", Moscow, Russia. Electronic address: deyev@ibch.ru.
J Control Release ; 349: 475-485, 2022 09.
Article en En | MEDLINE | ID: mdl-35839934
Bismuth-based compounds are considered to be the best candidates for computed tomography (CT) imaging of gastrointestinal (GI) tract due to high X-ray absorption. Here, we report the introduction of polymer-coated bismuth oxychloride (BiOCl) nanosheets for highly efficient CT imaging in healthy mice and animal with colitis. We demonstrate simple, low cost and fast aqueous synthesis protocol which provides gram-quantity yield of chemically stable BiOCl nanosheets. The developed contrast gives 2.55-fold better CT enhancement compared to conventional contrast with negligible in vivo toxicity. As a major finding we report a regioselective CT imaging of GI tract by using nanoparticles coated with differentially charged polymers. Coating of nanoparticles with a positively charged polymer leads to their fast accumulation in small intestine, while the coating with negatively charged polymers stimulates prolonged stomach retention. We propose that this effect may be explained by a pH-controlled aggregation of nanoparticles in stomach. This feature may become the basis for advancement in clinical diagnosis of entire GI tract.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Polímeros / Bismuto Tipo de estudio: Guideline Límite: Animals Idioma: En Revista: J Control Release Asunto de la revista: FARMACOLOGIA Año: 2022 Tipo del documento: Article Pais de publicación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Polímeros / Bismuto Tipo de estudio: Guideline Límite: Animals Idioma: En Revista: J Control Release Asunto de la revista: FARMACOLOGIA Año: 2022 Tipo del documento: Article Pais de publicación: Países Bajos