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Age impacts left atrial functional remodeling in athletes.
Cousergue, Cynthia; Saloux, Eric; Reboursière, Emmanuel; Rocamora, Amélia; Milliez, Paul; Normand, Hervé; Hodzic, Amir.
Afiliación
  • Cousergue C; Department of Cardiology, Normandie Univ, UNICAEN, CHU Caen Normandie, Caen, France.
  • Saloux E; Department of Cardiology, Normandie Univ, UNICAEN, CHU Caen Normandie, Caen, France.
  • Reboursière E; EA4650 (SEILIRM), FHU REMOD-VHF, Caen, France.
  • Rocamora A; Normandie Univ, UNICAEN, Caen, France.
  • Milliez P; Department of Sports Medecine, Normandie Univ, UNICAEN, CHU Caen Normandie, Inserm Comete, GIP Cyceron, Caen, France.
  • Normand H; Centre de Recherche Clinique (CRC), CHU Caen Normandie, Caen, France.
  • Hodzic A; Department of Cardiology, Normandie Univ, UNICAEN, CHU Caen Normandie, Caen, France.
PLoS One ; 17(7): e0271628, 2022.
Article en En | MEDLINE | ID: mdl-35839256
AIM: Age-associated changes in cardiac filling and function are well known in the general population. Yet, the effect of aging on left atrial (LA) function, and its interaction with left ventricular (LV) adaptation, remain less described when combined with high-intensity chronic training. We aimed to analyze the effects of aging on LA and LV functions in trained athletes. METHODS AND RESULTS: Ninety-five healthy highly-trained athletes referred for resting echocardiography were included. Two groups of athletes were retrospectively defined based on age: young athletes aged <35 years (n = 54), and master athletes aged ≥35 years (n = 41). All subjects were questioned about their sports practice. Echocardiographic analysis of LV systolic and diastolic functions (2D-echo, 3D-echo, and Doppler), as well as LA 2D dimensions and phasic deformations assessed by speckle tracking, were analyzed. Master athletes (mean age = 46.3 ± 8.3 years, mean duration of sustained training = 13.7 ± 8.9 years) exhibited significantly stiffer LV and LA with reduced LV early diastolic functional parameters (ratio E/A, peak e', and ratio e'/a'), LA reservoir and conduit strain, whereas LA volume, LA contractile strain and LV peak a' were higher, compared to young athletes. Multivariate regression analysis confirmed that age was predictive of peak e', LA reservoir strain and LA conduit strain, independently of training variables. LA phasic strains were strongly associated with LV diastolic function. CONCLUSIONS: Regardless of chronic sports practice, master athletes exhibited age-related changes in LA function closely coupled to LV diastolic properties, which led to LV filling shifts to late diastole.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Función del Atrio Izquierdo / Remodelación Atrial Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Humans / Middle aged Idioma: En Revista: PLoS One Asunto de la revista: CIENCIA / MEDICINA Año: 2022 Tipo del documento: Article País de afiliación: Francia Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Función del Atrio Izquierdo / Remodelación Atrial Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Humans / Middle aged Idioma: En Revista: PLoS One Asunto de la revista: CIENCIA / MEDICINA Año: 2022 Tipo del documento: Article País de afiliación: Francia Pais de publicación: Estados Unidos