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Plasmablast Expansion Following the Tetravalent, Live-Attenuated Dengue Vaccine Butantan-DV in DENV-Naïve and DENV-Exposed Individuals in a Brazilian Cohort.
Silveira, Cássia G T; Magnani, Diogo M; Costa, Priscilla R; Avelino-Silva, Vivian I; Ricciardi, Michael J; Timenetsky, Maria do Carmo S T; Goulart, Raphaella; Correia, Carolina A; Marmorato, Mariana P; Ferrari, Lilian; Nakagawa, Zelinda B; Tomiyama, Claudia; Tomiyama, Helena; Kalil, Jorge; Palacios, Ricardo; Precioso, Alexander R; Watkins, David I; Kallás, Esper G.
Afiliación
  • Silveira CGT; Division of Clinical Immunology and Allergy, School of Medicine, University of São Paulo, São Paulo, Brazil.
  • Magnani DM; Department of Pathology, University of Miami Miller School of Medicine, Miami, FL, United States.
  • Costa PR; Division of Clinical Immunology and Allergy, School of Medicine, University of São Paulo, São Paulo, Brazil.
  • Avelino-Silva VI; Department of Infectious and Parasitic Diseases, School of Medicine, University of São Paulo, São Paulo, Brazil.
  • Ricciardi MJ; Department of Pathology, University of Miami Miller School of Medicine, Miami, FL, United States.
  • Timenetsky MDCST; Virology Centre, Instituto Adolfo Lutz, São Paulo, Brazil.
  • Goulart R; Division of Clinical Immunology and Allergy, School of Medicine, University of São Paulo, São Paulo, Brazil.
  • Correia CA; Division of Clinical Immunology and Allergy, School of Medicine, University of São Paulo, São Paulo, Brazil.
  • Marmorato MP; Division of Clinical Immunology and Allergy, School of Medicine, University of São Paulo, São Paulo, Brazil.
  • Ferrari L; Division of Clinical Immunology and Allergy, School of Medicine, University of São Paulo, São Paulo, Brazil.
  • Nakagawa ZB; Division of Clinical Immunology and Allergy, School of Medicine, University of São Paulo, São Paulo, Brazil.
  • Tomiyama C; Division of Clinical Immunology and Allergy, School of Medicine, University of São Paulo, São Paulo, Brazil.
  • Tomiyama H; Division of Clinical Immunology and Allergy, School of Medicine, University of São Paulo, São Paulo, Brazil.
  • Kalil J; Division of Clinical Immunology and Allergy, School of Medicine, University of São Paulo, São Paulo, Brazil.
  • Palacios R; Division of Clinical Trials and Pharmacovigilance, Instituto Butantan, São Paulo, Brazil.
  • Precioso AR; Division of Clinical Trials and Pharmacovigilance, Instituto Butantan, São Paulo, Brazil.
  • Watkins DI; Pediatrics Department, School of Medicine, University of São Paulo, São Paulo, Brazil.
  • Kallás EG; Department of Pathology, University of Miami Miller School of Medicine, Miami, FL, United States.
Front Immunol ; 13: 908398, 2022.
Article en En | MEDLINE | ID: mdl-35837409
An effective vaccine against the dengue virus (DENV) should induce a balanced, long-lasting antibody (Ab) response against all four viral serotypes. The burst of plasmablasts in the peripheral blood after vaccination may reflect enriched vaccine-specific Ab secreting cells. Here we characterize the acute plasmablast responses from naïve and DENV-exposed individuals following immunization with the live attenuated tetravalent (LAT) Butantan DENV vaccine (Butantan-DV). The frequency of circulating plasmablasts was determined by flow cytometric analysis of fresh whole blood specimens collected from 40 participants enrolled in the Phase II Butantan-DV clinical trial (NCT01696422) before and after (days 6, 12, 15 and 22) vaccination. We observed a peak in the number of circulating plasmablast at day 15 after vaccination in both the DENV naïve and the DENV-exposed vaccinees. DENV-exposed vaccinees experienced a significantly higher plasmablast expansion. In the DENV-naïve vaccinees, plasmablasts persisted for approximately three weeks longer than among DENV-exposed volunteers. Our findings indicate that the Butantan-DV can induce plasmablast responses in both DENV-naïve and DENV-exposed individuals and demonstrate the influence of pre-existing DENV immunity on Butantan DV-induced B-cell responses.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Virus del Dengue / Vacunas contra el Dengue Límite: Humans País/Región como asunto: America do sul / Brasil Idioma: En Revista: Front Immunol Año: 2022 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Virus del Dengue / Vacunas contra el Dengue Límite: Humans País/Región como asunto: America do sul / Brasil Idioma: En Revista: Front Immunol Año: 2022 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Suiza