Salidroside ameliorates orthopedic surgery-induced cognitive dysfunction by activating adenosine 5'-monophosphate-activated protein kinase signaling in mice.

Pan, Cai-Long; Dai, Guo-Liang; Zhang, Hui-Wen; Zhang, Chen-Yang; Meng, Qing-Hai; Xu, Lu; Xu, Ning; Zhang, Yong; Tan, Qi-Lian; Wang, Xiao-Liang; Zhang, Zhi-Yuan

Pan, Cai-Long; Dai, Guo-Liang; Zhang, Hui-Wen; Zhang, Chen-Yang; Meng, Qing-Hai; Xu, Lu; Xu, Ning; Zhang, Yong; Tan, Qi-Lian; Wang, Xiao-Liang; Zhang, Zhi-Yuan.

Afiliación

Pan CL; School of Basic Medical Sciences, Nanjing Medical University, Nanjing, 211166, China.
Dai GL; Department of Clinical Pharmacology, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, 210029, China.
Zhang HW; School of Basic Medical Sciences, Nanjing Medical University, Nanjing, 211166, China.
Zhang CY; School of Basic Medical Sciences, Nanjing Medical University, Nanjing, 211166, China.
Meng QH; School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, 210023, China.
Xu L; School of Basic Medical Sciences, Nanjing Medical University, Nanjing, 211166, China.
Xu N; School of Basic Medical Sciences, Nanjing Medical University, Nanjing, 211166, China.
Zhang Y; Department of Anesthesiology, Nanjing First Hospital, Nanjing Medical University, Nanjing, 210029, China.
Tan QL; Department of Anesthesiology, Nanjing First Hospital, Nanjing Medical University, Nanjing, 210029, China.
Wang XL; Department of Anesthesiology, Nanjing First Hospital, Nanjing Medical University, Nanjing, 210029, China.
Zhang ZY; School of Basic Medical Sciences, Nanjing Medical University, Nanjing, 211166, China. Electronic address: zzy@njmu.edu.cn.

Eur J Pharmacol ; 929: 175148, 2022 Aug 15.

Article en En | MEDLINE | ID: mdl-35834964

Asunto(s)

Disfunción Cognitiva; Procedimientos Ortopédicos; Proteínas Quinasas Activadas por AMP/metabolismo; Adenosina/metabolismo; Animales; Antiinflamatorios/farmacología; Disfunción Cognitiva/tratamiento farmacológico; Disfunción Cognitiva/etiología; Disfunción Cognitiva/metabolismo; Glucósidos; Ratones; Ratones Endogámicos C57BL; Microglía; Simulación del Acoplamiento Molecular; Fenoles

Palabras clave

AMPK; Microglia; PPARÎ³; Perioperative neurocognitive disorders; Salidroside

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Procedimientos Ortopédicos / Disfunción Cognitiva Tipo de estudio: Etiology_studies Límite: Animals Idioma: En Revista: Eur J Pharmacol Año: 2022 Tipo del documento: Article País de afiliación: China Pais de publicación: Países Bajos

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