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Effectiveness and cost-effectiveness of universal school-based mindfulness training compared with normal school provision in reducing risk of mental health problems and promoting well-being in adolescence: the MYRIAD cluster randomised controlled trial.
Kuyken, Willem; Ball, Susan; Crane, Catherine; Ganguli, Poushali; Jones, Benjamin; Montero-Marin, Jesus; Nuthall, Elizabeth; Raja, Anam; Taylor, Laura; Tudor, Kate; Viner, Russell M; Allwood, Matthew; Aukland, Louise; Dunning, Darren; Casey, Tríona; Dalrymple, Nicola; De Wilde, Katherine; Farley, Eleanor-Rose; Harper, Jennifer; Kappelmann, Nils; Kempnich, Maria; Lord, Liz; Medlicott, Emma; Palmer, Lucy; Petit, Ariane; Philips, Alice; Pryor-Nitsch, Isobel; Radley, Lucy; Sonley, Anna; Shackleford, Jem; Tickell, Alice; Blakemore, Sarah-Jayne; Team, The Myriad; Ukoumunne, Obioha C; Greenberg, Mark T; Ford, Tamsin; Dalgleish, Tim; Byford, Sarah; Williams, J Mark G.
Afiliación
  • Kuyken W; Department of Psychiatry, Warneford Hospital, University of Oxford, Oxford, UK willem.kuyken@psych.ox.ac.uk.
  • Ball S; NIHR Applied Research Collaboration South West Peninsula (PenARC), University of Exeter, Exeter, Devon, UK.
  • Crane C; Department of Psychiatry, Warneford Hospital, University of Oxford, Oxford, UK.
  • Ganguli P; King's College London, King's Health Economics, Institute of Psychiatry, Psychology and Neuroscience, De Crespigny Park, London, UK.
  • Jones B; NIHR Applied Research Collaboration South West Peninsula (PenARC), University of Exeter, Exeter, Devon, UK.
  • Montero-Marin J; Department of Psychiatry, Warneford Hospital, University of Oxford, Oxford, UK.
  • Nuthall E; Teaching, Research and Innovation Unit, Parc Sanitari Sant Joan de Déu, Sant Boi de Llobregat, Spain.
  • Raja A; Department of Psychiatry, Warneford Hospital, University of Oxford, Oxford, UK.
  • Taylor L; Department of Psychiatry, Warneford Hospital, University of Oxford, Oxford, UK.
  • Tudor K; Department of Psychiatry, Warneford Hospital, University of Oxford, Oxford, UK.
  • Viner RM; Department of Psychiatry, Warneford Hospital, University of Oxford, Oxford, UK.
  • Allwood M; Population, Policy & Practice research programme, UCL Great Ormond St. Institute of Child Health, London, UK.
  • Aukland L; Department of Psychiatry, Warneford Hospital, University of Oxford, Oxford, UK.
  • Dunning D; Department of Psychiatry, Warneford Hospital, University of Oxford, Oxford, UK.
  • Casey T; Medical Research Council Cognition and Brain Sciences Unit, University of Cambridge, Cambridge, UK.
  • Dalrymple N; Department of Psychiatry, Warneford Hospital, University of Oxford, Oxford, UK.
  • De Wilde K; Department of Psychiatry, Warneford Hospital, University of Oxford, Oxford, UK.
  • Farley ER; Department of Psychiatry, Warneford Hospital, University of Oxford, Oxford, UK.
  • Harper J; Department of Psychiatry, Warneford Hospital, University of Oxford, Oxford, UK.
  • Kappelmann N; Department of Psychiatry, Warneford Hospital, University of Oxford, Oxford, UK.
  • Kempnich M; Department of Psychiatry, Warneford Hospital, University of Oxford, Oxford, UK.
  • Lord L; Department of Psychiatry, Warneford Hospital, University of Oxford, Oxford, UK.
  • Medlicott E; Department of Psychiatry, Warneford Hospital, University of Oxford, Oxford, UK.
  • Palmer L; Department of Psychiatry, Warneford Hospital, University of Oxford, Oxford, UK.
  • Petit A; Department of Psychiatry, Warneford Hospital, University of Oxford, Oxford, UK.
  • Philips A; Department of Psychiatry, Warneford Hospital, University of Oxford, Oxford, UK.
  • Pryor-Nitsch I; Department of Psychiatry, Warneford Hospital, University of Oxford, Oxford, UK.
  • Radley L; Department of Psychiatry, Warneford Hospital, University of Oxford, Oxford, UK.
  • Sonley A; Department of Psychiatry, Warneford Hospital, University of Oxford, Oxford, UK.
  • Shackleford J; Department of Psychiatry, Warneford Hospital, University of Oxford, Oxford, UK.
  • Tickell A; Department of Psychiatry, Warneford Hospital, University of Oxford, Oxford, UK.
  • Blakemore SJ; Department of Psychiatry, Warneford Hospital, University of Oxford, Oxford, UK.
  • Team TM; Department of Psychology, University of Cambridge, Cambridge, UK.
  • Ukoumunne OC; UCL Institute of Cognitive Neuroscience, London, UK.
  • Greenberg MT; Department of Psychiatry, Warneford Hospital, University of Oxford, Oxford, UK.
  • Ford T; NIHR Applied Research Collaboration South West Peninsula (PenARC), University of Exeter, Exeter, Devon, UK.
  • Dalgleish T; Department of Human Development and Family Studies, The Pennsylvania State University, University Park, Pennsylvania, USA.
  • Byford S; Department of Psychiatry, University of Cambridge, Cambridge Biomedical Campus, Cambridge, UK.
  • Williams JMG; Medical Research Council Cognition and Brain Sciences Unit, University of Cambridge, Cambridge, UK.
Evid Based Ment Health ; 2022 Jul 12.
Article en En | MEDLINE | ID: mdl-35820992
BACKGROUND: Systematic reviews suggest school-based mindfulness training (SBMT) shows promise in promoting student mental health. OBJECTIVE: The My Resilience in Adolescence (MYRIAD) Trial evaluated the effectiveness and cost-effectiveness of SBMT compared with teaching-as-usual (TAU). METHODS: MYRIAD was a parallel group, cluster-randomised controlled trial. Eighty-five eligible schools consented and were randomised 1:1 to TAU (43 schools, 4232 students) or SBMT (42 schools, 4144 students), stratified by school size, quality, type, deprivation and region. Schools and students (mean (SD); age range=12.2 (0.6); 11-14 years) were broadly UK population-representative. Forty-three schools (n=3678 pupils; 86.9%) delivering SBMT, and 41 schools (n=3572; 86.2%) delivering TAU, provided primary end-point data. SBMT comprised 10 lessons of psychoeducation and mindfulness practices. TAU comprised standard social-emotional teaching. Participant-level risk for depression, social-emotional-behavioural functioning and well-being at 1 year follow-up were the co-primary outcomes. Secondary and economic outcomes were included. FINDINGS: Analysis of 84 schools (n=8376 participants) found no evidence that SBMT was superior to TAU at 1 year. Standardised mean differences (intervention minus control) were: 0.005 (95% CI -0.05 to 0.06) for risk for depression; 0.02 (-0.02 to 0.07) for social-emotional-behavioural functioning; and 0.02 (-0.03 to 0.07) for well-being. SBMT had a high probability of cost-effectiveness (83%) at a willingness-to-pay threshold of £20 000 per quality-adjusted life year. No intervention-related adverse events were observed. CONCLUSIONS: Findings do not support the superiority of SBMT over TAU in promoting mental health in adolescence. CLINICAL IMPLICATIONS: There is need to ask what works, for whom and how, as well as considering key contextual and implementation factors. TRIAL REGISTRATION: Current controlled trials ISRCTN86619085. This research was funded by the Wellcome Trust (WT104908/Z/14/Z and WT107496/Z/15/Z).
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Clinical_trials / Etiology_studies / Health_economic_evaluation / Risk_factors_studies Aspecto: Patient_preference Idioma: En Revista: Evid Based Ment Health Asunto de la revista: PSICOLOGIA Año: 2022 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Clinical_trials / Etiology_studies / Health_economic_evaluation / Risk_factors_studies Aspecto: Patient_preference Idioma: En Revista: Evid Based Ment Health Asunto de la revista: PSICOLOGIA Año: 2022 Tipo del documento: Article Pais de publicación: Reino Unido