The utility of postoperative systemic antibiotic prophylaxis following cardiovascular implantable electronic device implantation: A systematic review and meta-analysis.

Chesdachai, Supavit; Go, John R; Hassett, Leslie C; Baddour, Larry M; DeSimone, Daniel C

Chesdachai, Supavit; Go, John R; Hassett, Leslie C; Baddour, Larry M; DeSimone, Daniel C.

Afiliación

Chesdachai S; Division of Public Health, Infectious Diseases and Occupational Medicine, Department of Medicine, Mayo Clinic, Rochester, Minnesota, USA.
Go JR; Division of Public Health, Infectious Diseases and Occupational Medicine, Department of Medicine, Mayo Clinic, Rochester, Minnesota, USA.
Hassett LC; Mayo Clinic Libraries, Mayo Clinic, Rochester, Minnesota, USA.
Baddour LM; Division of Public Health, Infectious Diseases and Occupational Medicine, Department of Medicine, Mayo Clinic, Rochester, Minnesota, USA.
DeSimone DC; Department of Cardiovascular Disease, Mayo Clinic, Rochester, Minnesota, USA.

Pacing Clin Electrophysiol ; 45(8): 940-949, 2022 08.

Article en En | MEDLINE | ID: mdl-35819103

RESUMEN

BACKGROUND: There is insufficient evidence regarding postoperative systemic antibiotic prophylaxis use for more than 24 h following cardiovascular implantable electronic devices (CIED) implantation and its impact on infection prevention. However, this strategy remains a common practice in many institutions. METHODS: We conducted a systematic review and meta-analysis including studies that compared the outcomes of patients: (1) who received preoperative plus 24 h or more of postoperative antibiotic prophylaxis (intervention group); and (2) who received either preoperative only or preoperative plus less than 24 h of antibiotic prophylaxis (control group). Risk of bias was assessed with ROBINS-I and ROB-2 tools. Risk ratio (RR) was pooled using random-effect meta-analyses with inverse variance method. RESULTS: Eight studies that included two randomized controlled trials (RCTs) and six cohort studies with a total of 26,187 patients were included in the analysis. Overall, there were no differences in outcomes between the two groups, which included rates of CIED infection (RR 0.77, 95% CI 0.42, 1.42), mortality (RR 1.19, 95% CI 0.69, 2.06), pocket hematoma (RR 1.15, 95% CI 0.44, 3.00) or reintervention (RR 0.87, 95% CI 0.22, 3.46). Of note, the results were primarily impacted by the larger RCT. CONCLUSIONS: There was no benefit of postoperative antibiotic prophylaxis for more than 24 h following CIED implantation in the current systematic review and meta-analysis. This supports the practice advocated by current guidelines which foster antibiotic stewardship and may result in reductions of adverse drug events, selection for antibiotic resistance, and financial costs of prolonged postoperative antibiotic prophylaxis.

Asunto(s)

Profilaxis Antibiótica; Electrónica; Antibacterianos/uso terapéutico; Profilaxis Antibiótica/métodos; Estudios de Cohortes; Humanos; Ensayos Clínicos Controlados Aleatorios como Asunto

Palabras clave

CIED; antibiotic; cardiovascular implantable electronic device; infection; postoperative; prophylaxis

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Profilaxis Antibiótica / Electrónica Tipo de estudio: Clinical_trials / Etiology_studies / Guideline / Incidence_studies / Observational_studies / Risk_factors_studies / Systematic_reviews Límite: Humans Idioma: En Revista: Pacing Clin Electrophysiol Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos

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