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A novel diagnostic tool for hyaline vascular Castleman disease versus lymphoma based on contrast-enhanced computed tomography in neck mass.
Lin, Huan-Yu; Liao, Pei-Shao; Shih, Liang-Chun; Hua, Chun-Hung; Tsai, Ming-Hsui; Lin, Chia-Der.
Afiliación
  • Lin HY; Department of Otolaryngology-Head and Neck Surgery, China Medical University Hospital, Taichung, Taiwan, ROC.
  • Liao PS; Department of Otolaryngology-Head and Neck Surgery, School of Medicine, China Medical University Hospital, Taichung, Taiwan, ROC.
  • Shih LC; Department of Otolaryngology-Head and Neck Surgery, China Medical University Hospital, Taichung, Taiwan, ROC.
  • Hua CH; Department of Otolaryngology-Head and Neck Surgery, School of Medicine, China Medical University Hospital, Taichung, Taiwan, ROC.
  • Tsai MH; Department of Otolaryngology-Head and Neck Surgery, China Medical University Hospital, Taichung, Taiwan, ROC.
  • Lin CD; Department of Otolaryngology-Head and Neck Surgery, School of Medicine, China Medical University Hospital, Taichung, Taiwan, ROC.
J Chin Med Assoc ; 85(9): 935-938, 2022 09 01.
Article en En | MEDLINE | ID: mdl-35818930
BACKGROUND: Castleman disease and lymphoma each have a distinct treatment plan; however, they share the same features on contrast-enhanced computed tomography. METHODS: To assess the quantitative outcomes of Castleman disease versus lymphoma using contrast-enhanced computed tomography based on Hounsfield units (HU). We retrospectively reviewed eight patients with unicentric Castleman disease and 30 patients with lymphoma based on pathological diagnosis at China Medical University Hospital between 2015 and 2020. Preoperative computed tomography with contrast scans was reviewed, and the HU of each tumor were measured. RESULTS: This study included eight patients with unicentric Castleman disease (four men and four women; mean age, 33 years) and 25 patients with lymphoma (11 men and 14 women; mean age, 53 years). There was no significant difference in heterogeneity between the two diseases (0.161 ± 0.052 vs 0.239 ± 0.063, p = 0.22); however, enhancement in Castleman disease was higher than that in lymphoma (126.40 ± 31.90 vs 74.19 ± 7.11, p < 0.001), providing a very good diagnostic tool (cutoff point at 88.5-91.3, sensitivity 0.86/specificity 0.88). Furthermore, we found a highly linear relationship in Castleman disease, which was not noted in lymphoma. CONCLUSION: The value of HU provides a good diagnostic tool for the differential diagnosis of Castleman disease versus lymphoma in the neck lymph nodes. Considering the linear relationship in Castleman disease, an increasingly accurate differential diagnosis can be made.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad de Castleman / Linfoma Tipo de estudio: Diagnostic_studies / Observational_studies Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: J Chin Med Assoc Asunto de la revista: MEDICINA Año: 2022 Tipo del documento: Article Pais de publicación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad de Castleman / Linfoma Tipo de estudio: Diagnostic_studies / Observational_studies Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: J Chin Med Assoc Asunto de la revista: MEDICINA Año: 2022 Tipo del documento: Article Pais de publicación: Países Bajos